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The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

Author

Listed:
  • Alex J. Kuo

    (Stanford University)

  • Jikui Song

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center
    Present address: Department of Biochemistry, University of California, Riverside, California 92521, USA.)

  • Peggie Cheung

    (Stanford University)

  • Satoko Ishibe-Murakami

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Sayumi Yamazoe

    (Stanford School of Medicine)

  • James K. Chen

    (Stanford School of Medicine)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Or Gozani

    (Stanford University)

Abstract

The ORC1 BAH domain is shown to be a module that recognizes a histone modification associated with replication origins, providing insight into the aetiology of Meier–Gorlin syndrome.

Suggested Citation

  • Alex J. Kuo & Jikui Song & Peggie Cheung & Satoko Ishibe-Murakami & Sayumi Yamazoe & James K. Chen & Dinshaw J. Patel & Or Gozani, 2012. "The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome," Nature, Nature, vol. 484(7392), pages 115-119, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7392:d:10.1038_nature10956
    DOI: 10.1038/nature10956
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    Cited by:

    1. Yue Wu & Qiongdan Zhang & Yuhan Lin & Wai Hei Lam & Yuanliang Zhai, 2024. "Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Aina Maria Mas & Enrique Goñi & Igor Ruiz de los Mozos & Aida Arcas & Luisa Statello & Jovanna González & Lorea Blázquez & Wei Ting Chelsea Lee & Dipika Gupta & Álvaro Sejas & Shoko Hoshina & Alexandr, 2023. "ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Zaida Vergara & María S. Gomez & Bénédicte Desvoyes & Joana Sequeira-Mendes & Kinda Masoud & Celina Costas & Sandra Noir & Elena Caro & Victoria Mora-Gil & Pascal Genschik & Crisanto Gutierrez, 2023. "Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Sai Li & Michael R. Wasserman & Olga Yurieva & Lu Bai & Michael E. O’Donnell & Shixin Liu, 2022. "Nucleosome-directed replication origin licensing independent of a consensus DNA sequence," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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