IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v483y2012i7391d10.1038_nature10927.html
   My bibliography  Save this article

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

Author

Listed:
  • Lidan Liu

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Jannes Ulbrich

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Judith Müller

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
    Present addresses: Netherlands Cancer Institute (NKI), Department of Molecular Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (J.M.); Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany (L.A.); European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 16 - 20139 Milan, Italy (T.R.K.).)

  • Torsten Wüstefeld

    (Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Hepatology and Endocrinology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany)

  • Lukas Aeberhard

    (Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, Berlin 13125, Germany
    Present addresses: Netherlands Cancer Institute (NKI), Department of Molecular Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (J.M.); Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany (L.A.); European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 16 - 20139 Milan, Italy (T.R.K.).)

  • Theresia R. Kress

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
    Present addresses: Netherlands Cancer Institute (NKI), Department of Molecular Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (J.M.); Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany (L.A.); European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 16 - 20139 Milan, Italy (T.R.K.).)

  • Nathiya Muthalagu

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Lukas Rycak

    (Institute of Molecular Biology and Tumor Research, Emil-Mannkopff-Str. 2, 35037 Marburg, Germany)

  • Ramona Rudalska

    (Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany)

  • Roland Moll

    (Institute for Pathology, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany)

  • Stefan Kempa

    (Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, Berlin 13125, Germany)

  • Lars Zender

    (Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Hepatology and Endocrinology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany)

  • Martin Eilers

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Daniel J. Murphy

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

Abstract

Oncogenic levels of MYC, the deregulation of which is implicated in many human tumours, are shown to establish a dependence on ARK5, offering insights into potential therapeutic strategies.

Suggested Citation

  • Lidan Liu & Jannes Ulbrich & Judith Müller & Torsten Wüstefeld & Lukas Aeberhard & Theresia R. Kress & Nathiya Muthalagu & Lukas Rycak & Ramona Rudalska & Roland Moll & Stefan Kempa & Lars Zender & Ma, 2012. "Deregulated MYC expression induces dependence upon AMPK-related kinase 5," Nature, Nature, vol. 483(7391), pages 608-612, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10927
    DOI: 10.1038/nature10927
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10927
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10927?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. William Senapedis & Kayleigh M. Gallagher & Elmer Figueroa & Jeremiah D. Farelli & Robert Lyng & J. Graeme Hodgson & Charles W. O’Donnell & Joseph V. Newman & Madison Pacaro & Stephen K. Siecinski & J, 2024. "Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Marine Lanfranchi & Sozerko Yandiev & Géraldine Meyer-Dilhet & Salma Ellouze & Martijn Kerkhofs & Raphael Dos Reis & Audrey Garcia & Camille Blondet & Alizée Amar & Anita Kneppers & Hélène Polvèche & , 2024. "The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10927. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.