IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v483y2012i7387d10.1038_nature10852.html
   My bibliography  Save this article

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Author

Listed:
  • Darwin Jeyaraj

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine
    Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Saptarsi M. Haldar

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Xiaoping Wan

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Mark D. McCauley

    (Baylor College of Medicine)

  • Jürgen A. Ripperger

    (University of Fribourg, CH-1700 Fribourg, Switzerland)

  • Kun Hu

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Yuan Lu

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Betty L. Eapen

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Nikunj Sharma

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

  • Eckhard Ficker

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Michael J. Cutler

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • James Gulick

    (Cincinnati Children’s Hospital Medical Center)

  • Atsushi Sanbe

    (Cincinnati Children’s Hospital Medical Center)

  • Jeffrey Robbins

    (Cincinnati Children’s Hospital Medical Center)

  • Sophie Demolombe

    (Institut de Pharmacologie Moléculaire et Cellulaire, UMR CNRS 6097, Université de Nice Sophia Antipolis)

  • Roman V. Kondratov

    (Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University)

  • Steven A. Shea

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Urs Albrecht

    (University of Fribourg, CH-1700 Fribourg, Switzerland)

  • Xander H. T. Wehrens

    (Baylor College of Medicine)

  • David S. Rosenbaum

    (Heart and Vascular Research Center, MetroHealth campus of Case Western Reserve University)

  • Mukesh K. Jain

    (Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine)

Abstract

Circadian rhythmicity of cardiac ion-channel expression and of an index of myocardial repolarization is under the control of Klf15, a clock-dependent oscillator that is required for generating transient outward potassium current, and deficiencies or excesses of which cause loss of rhythmic variation in myocardial and abnormal repolarization, and an enhanced susceptibility to ventricular arrhythmias.

Suggested Citation

  • Darwin Jeyaraj & Saptarsi M. Haldar & Xiaoping Wan & Mark D. McCauley & Jürgen A. Ripperger & Kun Hu & Yuan Lu & Betty L. Eapen & Nikunj Sharma & Eckhard Ficker & Michael J. Cutler & James Gulick & At, 2012. "Circadian rhythms govern cardiac repolarization and arrhythmogenesis," Nature, Nature, vol. 483(7387), pages 96-99, March.
  • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10852
    DOI: 10.1038/nature10852
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10852
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature10852?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Carlos Sánchez & Alfonso Bueno-Orovio & Erich Wettwer & Simone Loose & Jana Simon & Ursula Ravens & Esther Pueyo & Blanca Rodriguez, 2014. "Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-14, August.
    2. John Walmsley & Jose F Rodriguez & Gary R Mirams & Kevin Burrage & Igor R Efimov & Blanca Rodriguez, 2013. "mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-11, February.
    3. Nor Amira Syahira Mohd Azmi & Norsham Juliana & Sahar Azmani & Nadia Mohd Effendy & Izuddin Fahmy Abu & Nur Islami Mohd Fahmi Teng & Srijit Das, 2021. "Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    4. Feng Gao & Tian Liang & Yao Wei Lu & Xuyang Fu & Xiaoxuan Dong & Linbin Pu & Tingting Hong & Yuxia Zhou & Yu Zhang & Ning Liu & Feng Zhang & Jianming Liu & Andrea P. Malizia & Hong Yu & Wei Zhu & Doug, 2023. "A defect in mitochondrial protein translation influences mitonuclear communication in the heart," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10852. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.