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Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Author

Listed:
  • Warren A. Whyte

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Massachusetts Institute of Technology)

  • Steve Bilodeau

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • David A. Orlando

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Heather A. Hoke

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Massachusetts Institute of Technology)

  • Garrett M. Frampton

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Massachusetts Institute of Technology)

  • Charles T. Foster

    (Adolf-Butenandt Institut, Ludwig-Maximilians-Universität München, 80336 Munich, Germany
    University of Leicester, Leicester LE1 9HN, UK)

  • Shaun M. Cowley

    (University of Leicester, Leicester LE1 9HN, UK)

  • Richard A. Young

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Massachusetts Institute of Technology)

Abstract

In embryonic stem cells, the histone demethylase LSD1 occupies the enhancers of active genes and, together with the NuRD complex, decommissions the enhancers during differentiation.

Suggested Citation

  • Warren A. Whyte & Steve Bilodeau & David A. Orlando & Heather A. Hoke & Garrett M. Frampton & Charles T. Foster & Shaun M. Cowley & Richard A. Young, 2012. "Enhancer decommissioning by LSD1 during embryonic stem cell differentiation," Nature, Nature, vol. 482(7384), pages 221-225, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10805
    DOI: 10.1038/nature10805
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    Citations

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    Cited by:

    1. Ziad Ibrahim & Tao Wang & Olivier Destaing & Nicola Salvi & Naghmeh Hoghoughi & Clovis Chabert & Alexandra Rusu & Jinjun Gao & Leonardo Feletto & Nicolas Reynoird & Thomas Schalch & Yingming Zhao & Ma, 2022. "Structural insights into p300 regulation and acetylation-dependent genome organisation," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    2. Cheng Zeng & Jiwei Chen & Emmalee W. Cooke & Arijita Subuddhi & Eliana T. Roodman & Fei Xavier Chen & Kaixiang Cao, 2023. "Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Beatriz del Blanco & Sergio Niñerola & Ana M. Martín-González & Juan Paraíso-Luna & Minji Kim & Rafael Muñoz-Viana & Carina Racovac & Jose V. Sanchez-Mut & Yijun Ruan & Ángel Barco, 2024. "Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Abrar Aljahani & Peng Hua & Magdalena A. Karpinska & Kimberly Quililan & James O. J. Davies & A. Marieke Oudelaar, 2022. "Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Sandhya Malla & Kanchan Kumari & Carlos A. García-Prieto & Jonatan Caroli & Anna Nordin & Trinh T. T. Phan & Devi Prasad Bhattarai & Carlos Martinez-Gamero & Eshagh Dorafshan & Stephanie Stransky & Da, 2024. "The scaffolding function of LSD1 controls DNA methylation in mouse ESCs," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    6. Hsiao-Yun Chen & Yavuz T. Durmaz & Yixiang Li & Amin H. Sabet & Amir Vajdi & Thomas Denize & Emily Walton & Yasmin Nabil Laimon & John G. Doench & Navin R. Mahadevan & Julie-Aurore Losman & David A. B, 2022. "Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    7. Tiantian Jing & Dianhui Wei & Xiaoli Xu & Chengsi Wu & Lili Yuan & Yiwen Huang & Yizhen Liu & Yanyi Jiang & Boshi Wang, 2024. "Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    8. Xue Zhong & Nagesh Peddada & Jianhui Wang & James J. Moresco & Xiaowei Zhan & John M. Shelton & Jeffrey A. SoRelle & Katie Keller & Danielle Renee Lazaro & Eva Marie Y. Moresco & Jin Huk Choi & Bruce , 2023. "OVOL2 sustains postnatal thymic epithelial cell identity," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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