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The DNA damage response and cancer therapy

Author

Listed:
  • Christopher J. Lord

    (The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research)

  • Alan Ashworth

    (The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research)

Abstract

Genomic instability is one of the most pervasive characteristics of tumour cells and is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. Although these processes drive genomic instability and ultimately the disease process, they also provide therapeutic opportunities. A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.

Suggested Citation

  • Christopher J. Lord & Alan Ashworth, 2012. "The DNA damage response and cancer therapy," Nature, Nature, vol. 481(7381), pages 287-294, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10760
    DOI: 10.1038/nature10760
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    Cited by:

    1. Faye M. Walker & Lays Martin Sobral & Etienne Danis & Bridget Sanford & Sahiti Donthula & Ilango Balakrishnan & Dong Wang & Angela Pierce & Sana D. Karam & Soudabeh Kargar & Natalie J. Serkova & Nicho, 2024. "Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Ivo A. Hendriks & Sara C. Buch-Larsen & Evgeniia Prokhorova & Jonas D. Elsborg & Alexandra K.L.F.S. Rebak & Kang Zhu & Dragana Ahel & Claudia Lukas & Ivan Ahel & Michael L. Nielsen, 2021. "The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Hyo Geun Choi & Jung Ho Park & Yeon Ju Choi & Yong Joon Suh, 2021. "Association of Family History with the Development of Breast Cancer: A Cohort Study of 129,374 Women in KoGES Data," IJERPH, MDPI, vol. 18(12), pages 1-9, June.
    4. Fangyuan Li & Heng Sun & Jiafeng Ren & Bo Zhang & Xi Hu & Chunyan Fang & Jiyoung Lee & Hongzhou Gu & Daishun Ling, 2022. "A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Ami G Sangster & Robert J Gooding & Andrew Garven & Hamid Ghaedi & David M Berman & Scott K Davey, 2022. "Mutually exclusive mutation profiles define functionally related genes in muscle invasive bladder cancer," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-17, January.
    6. Hanrui Zhang & Julian Kreis & Sven-Eric Schelhorn & Heike Dahmen & Thomas Grombacher & Michael Zühlsdorf & Frank T. Zenke & Yuanfang Guan, 2023. "Mapping combinatorial drug effects to DNA damage response kinase inhibitors," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    7. Yaping Huang & Changzheng Lu & Hanzhi Wang & Liya Gu & Yang-Xin Fu & Guo-Min Li, 2023. "DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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