IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7378d10.1038_nature10702.html
   My bibliography  Save this article

Rethinking amide bond synthesis

Author

Listed:
  • Vijaya R. Pattabiraman

    (Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich, Switzerland)

  • Jeffrey W. Bode

    (Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich, Switzerland)

Abstract

Recent advances in amide-bond-forming reactions are reviewed and summarized, highlighting the successful implementation of new synthetic methodologies and the limitations that need to be overcome to efficiently make the next generation of conventional small-molecule pharmaceuticals, therapeutic peptides, and natural and non-natural proteins.

Suggested Citation

  • Vijaya R. Pattabiraman & Jeffrey W. Bode, 2011. "Rethinking amide bond synthesis," Nature, Nature, vol. 480(7378), pages 471-479, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10702
    DOI: 10.1038/nature10702
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10702
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10702?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xin Liu & Yan Jiao & Yao Zheng & Mietek Jaroniec & Shi-Zhang Qiao, 2022. "Mechanism of C-N bonds formation in electrocatalytic urea production revealed by ab initio molecular dynamics simulation," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Nannan Meng & Jiang Shao & Hongjiao Li & Yuting Wang & Xiaoli Fu & Cuibo Liu & Yifu Yu & Bin Zhang, 2022. "Electrosynthesis of formamide from methanol and ammonia under ambient conditions," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    3. Meng He & Yongmeng Wu & Rui Li & Yuting Wang & Cuibo Liu & Bin Zhang, 2023. "Aqueous pulsed electrochemistry promotes C−N bond formation via a one-pot cascade approach," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Pritha Ghosh & Nishant Raj & Hitesh Verma & Monika Patel & Sohini Chakraborti & Bhavesh Khatri & Chandrashekar M. Doreswamy & S. R. Anandakumar & Srinivas Seekallu & M. B. Dinesh & Gajanan Jadhav & Pr, 2023. "An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Jiao Lan & Zengxi Wei & Ying-Rui Lu & DeChao Chen & Shuangliang Zhao & Ting-Shan Chan & Yongwen Tan, 2023. "Efficient electrosynthesis of formamide from carbon monoxide and nitrite on a Ru-dispersed Cu nanocluster catalyst," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    6. Yuxing Cai & Yuxin Zhao & Kai Tang & Hong Zhang & Xueling Mo & Jiean Chen & Yong Huang, 2024. "Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene," Nature Communications, Nature, vol. 15(1), pages 1-7, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10702. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.