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GlcNAcylation of histone H2B facilitates its monoubiquitination

Author

Listed:
  • Ryoji Fujiki

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Waka Hashiba

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Hiroki Sekine

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Atsushi Yokoyama

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Toshihiro Chikanishi

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Saya Ito

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Yuuki Imai

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Jaehoon Kim

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Housheng Hansen He

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Katsuhide Igarashi

    (National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan)

  • Jun Kanno

    (National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan)

  • Fumiaki Ohtake

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Hirochika Kitagawa

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Robert G. Roeder

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Myles Brown

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Shigeaki Kato

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    ERATO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan)

Abstract

Genome-wide analysis shows that H2B S112 O-linked to N-acetylglucosamine is frequently located near transcribed genes, suggesting that histone GlcNAcylation facilitates transcription of the genes.

Suggested Citation

  • Ryoji Fujiki & Waka Hashiba & Hiroki Sekine & Atsushi Yokoyama & Toshihiro Chikanishi & Saya Ito & Yuuki Imai & Jaehoon Kim & Housheng Hansen He & Katsuhide Igarashi & Jun Kanno & Fumiaki Ohtake & Hir, 2011. "GlcNAcylation of histone H2B facilitates its monoubiquitination," Nature, Nature, vol. 480(7378), pages 557-560, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10656
    DOI: 10.1038/nature10656
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    Cited by:

    1. Shuhei Onishi & Kotone Uchiyama & Ko Sato & Chikako Okada & Shunsuke Kobayashi & Keisuke Hamada & Tomohiro Nishizawa & Osamu Nureki & Kazuhiro Ogata & Toru Sengoku, 2024. "Structure of the human Bre1 complex bound to the nucleosome," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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