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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Author

Listed:
  • Khoa D. Nguyen

    (Immunology Program, Stanford University
    Cardiovascular Research Institute, University of California)

  • Yifu Qiu

    (Cardiovascular Research Institute, University of California)

  • Xiaojin Cui

    (Cardiovascular Research Institute, University of California)

  • Y. P. Sharon Goh

    (Immunology Program, Stanford University
    Cardiovascular Research Institute, University of California)

  • Julia Mwangi

    (Cardiovascular Research Institute, University of California)

  • Tovo David

    (Cardiovascular Research Institute, University of California)

  • Lata Mukundan

    (Cardiovascular Research Institute, University of California)

  • Frank Brombacher

    (Institute of Infectious Disease and Molecular Medicine, University of Cape Town)

  • Richard M. Locksley

    (Howard Hughes Medical Institute, University of California
    University of California
    Microbiology & Immunology, University of California)

  • Ajay Chawla

    (Cardiovascular Research Institute, University of California
    University of California)

Abstract

Exposure to cold drives IL-4-mediated alternative macrophage activation and catecholamine secretion in brown and white adipose tissues to stimulate thermogenesis.

Suggested Citation

  • Khoa D. Nguyen & Yifu Qiu & Xiaojin Cui & Y. P. Sharon Goh & Julia Mwangi & Tovo David & Lata Mukundan & Frank Brombacher & Richard M. Locksley & Ajay Chawla, 2011. "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis," Nature, Nature, vol. 480(7375), pages 104-108, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10653
    DOI: 10.1038/nature10653
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    Citations

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    Cited by:

    1. Suyang Wu & Chen Qiu & Jiahao Ni & Wenli Guo & Jiyuan Song & Xingyin Yang & Yulin Sun & Yanjun Chen & Yunxia Zhu & Xiaoai Chang & Peng Sun & Chunxia Wang & Kai Li & Xiao Han, 2024. "M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Natasha M Girgis & Uma Mahesh Gundra & Lauren N Ward & Mynthia Cabrera & Ute Frevert & P'ng Loke, 2014. "Ly6Chigh Monocytes Become Alternatively Activated Macrophages in Schistosome Granulomas with Help from CD4+ Cells," PLOS Pathogens, Public Library of Science, vol. 10(6), pages 1-13, June.
    3. Prameladevi Chinnasamy & Isabel Casimiro & Dario F. Riascos-Bernal & Shreeganesh Venkatesh & Dippal Parikh & Alishba Maira & Aparna Srinivasan & Wei Zheng & Elena Tarabra & Haihong Zong & Smitha Jayak, 2023. "Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Shaojian Lin & Anke Zhang & Ling Yuan & Yufan Wang & Chuan Zhang & Junkun Jiang & Houshi Xu & Huiwen Yuan & Hui Yao & Qianying Zhang & Yong Zhang & Meiqing Lou & Ping Wang & Zhen-Ning Zhang & Bing Lua, 2022. "Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Jing Yan & Yuemei Zhang & Hairong Yu & Yicen Zong & Daixi Wang & Jiangfei Zheng & Li Jin & Xiangtian Yu & Caizhi Liu & Yi Zhang & Feng Jiang & Rong Zhang & Xiangnan Fang & Ting Xu & Mingyu Li & Jianzh, 2022. "GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    6. Xian Zhang & Songyuan Luo & Minjie Wang & Qiongqiong Cao & Zhixin Zhang & Qin Huang & Jie Li & Zhiyong Deng & Tianxiao Liu & Cong-Lin Liu & Mathilde Meppen & Amelie Vromman & Richard A. Flavell & Gökh, 2022. "Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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