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Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

Author

Listed:
  • Kerstin Berer

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

  • Marsilius Mues

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

  • Michail Koutrolos

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

  • Zakeya Al Rasbi

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

  • Marina Boziki

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

  • Caroline Johner

    (Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany)

  • Hartmut Wekerle

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

  • Gurumoorthy Krishnamoorthy

    (Max Planck Institute of Neurobiology, 82152 Martinsried, Germany)

Abstract

Role of gut bacteria in triggering multiple sclerosis There is controversy over the nature of the early stages of multiple sclerosis: some suggest that the initiation process involves primary changes in the central nervous system, others that pathogenesis originates in the immune system. Support for the latter concept comes from the finding that intact commensal microbiota are required for autoimmune disease in a spontaneous mouse model for relapsing–remitting multiple sclerosis. Microbial exposure is necessary but not sufficient for disease induction, which requires the presence of the target myelin autoantigen, MOG. The possible involvement of diet and microbiota in autoimmune disease may provide novel therapeutic approaches.

Suggested Citation

  • Kerstin Berer & Marsilius Mues & Michail Koutrolos & Zakeya Al Rasbi & Marina Boziki & Caroline Johner & Hartmut Wekerle & Gurumoorthy Krishnamoorthy, 2011. "Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination," Nature, Nature, vol. 479(7374), pages 538-541, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7374:d:10.1038_nature10554
    DOI: 10.1038/nature10554
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    Cited by:

    1. Felipe Papa Pellizoni & Aline Zazeri Leite & Nathália de Campos Rodrigues & Marcelo Jordão Ubaiz & Marina Ignácio Gonzaga & Nauyta Naomi Campos Takaoka & Vânia Sammartino Mariano & Wellington Pine Omo, 2021. "Detection of Dysbiosis and Increased Intestinal Permeability in Brazilian Patients with Relapsing–Remitting Multiple Sclerosis," IJERPH, MDPI, vol. 18(9), pages 1-17, April.
    2. Ruiqing Wang & Xinyu Yang & Jinting Liu & Fang Zhong & Chen Zhang & Yuhong Chen & Tao Sun & Chunyan Ji & Daoxin Ma, 2022. "Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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