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Distinct stem cells contribute to mammary gland development and maintenance

Author

Listed:
  • Alexandra Van Keymeulen

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Ana Sofia Rocha

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Marielle Ousset

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Benjamin Beck

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Gaëlle Bouvencourt

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Jason Rock

    (Duke University Medical Center)

  • Neha Sharma

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Sophie Dekoninck

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Cédric Blanpain

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
    Welbio, Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

Abstract

The mammary epithelium is composed of several cell lineages including luminal, alveolar and myoepithelial cells. Transplantation studies have suggested that the mammary epithelium is maintained by the presence of multipotent mammary stem cells. To define the cellular hierarchy of the mammary gland during physiological conditions, we performed genetic lineage-tracing experiments and clonal analysis of the mouse mammary gland during development, adulthood and pregnancy. We found that in postnatal unperturbed mammary gland, both luminal and myoepithelial lineages contain long-lived unipotent stem cells that display extensive renewing capacities, as demonstrated by their ability to clonally expand during morphogenesis and adult life as well as undergo massive expansion during several cycles of pregnancy. The demonstration that the mammary gland contains different types of long-lived stem cells has profound implications for our understanding of mammary gland physiology and will be instrumental in unravelling the cells at the origin of breast cancers.

Suggested Citation

  • Alexandra Van Keymeulen & Ana Sofia Rocha & Marielle Ousset & Benjamin Beck & Gaëlle Bouvencourt & Jason Rock & Neha Sharma & Sophie Dekoninck & Cédric Blanpain, 2011. "Distinct stem cells contribute to mammary gland development and maintenance," Nature, Nature, vol. 479(7372), pages 189-193, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7372:d:10.1038_nature10573
    DOI: 10.1038/nature10573
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    Citations

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    Cited by:

    1. Ana Sofia Rocha & Alejandro Collado-Solé & Osvaldo Graña-Castro & Jaime Redondo-Pedraza & Gonzalo Soria-Alcaide & Alex Cordero & Patricia G. Santamaría & Eva González-Suárez, 2023. "Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Luye An & Dahihm Kim & Leanne R. Donahue & Menansili Abraham Mejooli & Chi-Yong Eom & Nozomi Nishimura & Andrew C. White, 2024. "Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Andrew K. Beppu & Juanjuan Zhao & Changfu Yao & Gianni Carraro & Edo Israely & Anna Lucia Coelho & Katherine Drake & Cory M. Hogaboam & William C. Parks & Jay K. Kolls & Barry R. Stripp, 2023. "Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Elena Spina & Julia Simundza & Angela Incassati & Anupama Chandramouli & Matthias C. Kugler & Ziyan Lin & Alireza Khodadadi-Jamayran & Christine J. Watson & Pamela Cowin, 2022. "Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Ingrid Paine & Arnaud Chauviere & John Landua & Amulya Sreekumar & Vittorio Cristini & Jeffrey Rosen & Michael T Lewis, 2016. "A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud," PLOS Computational Biology, Public Library of Science, vol. 12(4), pages 1-23, April.
    6. Joseph G. Kern & Andrew M. Tilston-Lunel & Anthony Federico & Boting Ning & Amy Mueller & Grace B. Peppler & Eleni Stampouloglou & Nan Cheng & Randy L. Johnson & Marc E. Lenburg & Jennifer E. Beane & , 2022. "Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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