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STING is a direct innate immune sensor of cyclic di-GMP

Author

Listed:
  • Dara L. Burdette

    (University of California)

  • Kathryn M. Monroe

    (University of California)

  • Katia Sotelo-Troha

    (University of California)

  • Jeff S. Iwig

    (University of California
    Howard Hughes Medical Institute, University of California)

  • Barbara Eckert

    (University of California)

  • Mamoru Hyodo

    (Faculty of Pharmaceutical Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan)

  • Yoshihiro Hayakawa

    (Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa, Toyota 470-0392, Japan)

  • Russell E. Vance

    (University of California)

Abstract

Bacterial metabolites recognized by STING Cyclic dinucleotides, used as signalling molecules in bacteria but not in mammalian cells, are recognized by the mammalian innate immune system, triggering the production of type I interferon. Here the mammalian protein STING (stimulator of IFN genes) is identified as the direct molecular sensor for cyclic diguanylate monophosphate and other cyclic dinucleotides. Previously, STING was thought to act solely as a downstream signalling adaptor. Cyclic dinucleotides are potent immunostimulants, and may prove useful therapeutically.

Suggested Citation

  • Dara L. Burdette & Kathryn M. Monroe & Katia Sotelo-Troha & Jeff S. Iwig & Barbara Eckert & Mamoru Hyodo & Yoshihiro Hayakawa & Russell E. Vance, 2011. "STING is a direct innate immune sensor of cyclic di-GMP," Nature, Nature, vol. 478(7370), pages 515-518, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7370:d:10.1038_nature10429
    DOI: 10.1038/nature10429
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    Cited by:

    1. Matteo Gentili & Bingxu Liu & Malvina Papanastasiou & Deborah Dele-Oni & Marc A. Schwartz & Rebecca J. Carlson & Aziz M. Al’Khafaji & Karsten Krug & Adam Brown & John G. Doench & Steven A. Carr & Nir , 2023. "ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Qiao-qiao He & Yu Huang & Longyu Nie & Sheng Ren & Gang Xu & Feiyan Deng & Zhikui Cheng & Qi Zuo & Lin Zhang & Huanhuan Cai & Qiming Wang & Fubing Wang & Hong Ren & Huan Yan & Ke Xu & Li Zhou & Mengji, 2023. "MAVS integrates glucose metabolism and RIG-I-like receptor signaling," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Xia Li & Wenfang Yin & Junjie Desmond Lin & Yong Zhang & Quan Guo & Gerun Wang & Xiayu Chen & Binbin Cui & Mingfang Wang & Min Chen & Peng Li & Ya-Wen He & Wei Qian & Haibin Luo & Lian-Hui Zhang & Xue, 2023. "Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Martha Triantafilou & Joshi Ramanjulu & Lee M. Booty & Gisela Jimenez-Duran & Hakan Keles & Ken Saunders & Neysa Nevins & Emma Koppe & Louise K. Modis & G. Scott Pesiridis & John Bertin & Kathy Triant, 2022. "Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Rana Falahat & Anders Berglund & Patricio Perez-Villarroel & Ryan M. Putney & Imene Hamaidi & Sungjune Kim & Shari Pilon-Thomas & Glen N. Barber & James J. Mulé, 2023. "Epigenetic state determines the in vivo efficacy of STING agonist therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Bao-cun Zhang & Marlene F. Laursen & Lili Hu & Hossein Hazrati & Ryo Narita & Lea S. Jensen & Aida S. Hansen & Jinrong Huang & Yan Zhang & Xiangning Ding & Maimaitili Muyesier & Emil Nilsson & Agniesz, 2024. "Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Manas Sharma & Trason Thode & Alexis Weston & Mohan R Kaadige, 2018. "HematologicalDevelopment of Enpp1 Inhibitors as a Strategy to Activate Stimulator of Interferon Genes (STING) in Cancers and Other Diseases," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(1), pages 24-28, September.

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