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Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

Author

Listed:
  • Caroline J. Breitbach

    (Jennerex Inc., 450 Sansome Street, 16th floor)

  • James Burke

    (801 North 29th Street, Billings Clinic
    Present address: Jennerex Inc., 450 Sansome Street, 16th floor, San Francisco, California 94111, USA.)

  • Derek Jonker

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • Joe Stephenson

    (Cancer Centers of the Carolinas, 3 Butternut Drive)

  • Andrew R. Haas

    (University of Pennsylvania Medical Center, 3400 Spruce Street)

  • Laura Q. M. Chow

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • Jorge Nieva

    (801 North 29th Street, Billings Clinic)

  • Tae-Ho Hwang

    (Pusan National University, Jangjeon-dong GeumJeong-gu)

  • Anne Moon

    (Jennerex Inc., 450 Sansome Street, 16th floor)

  • Richard Patt

    (RadMD, 712 Hyde Park)

  • Adina Pelusio

    (Jennerex Inc., 450 Sansome Street, 16th floor)

  • Fabrice Le Boeuf

    (Ottawa Hospital Research Institute, 501 Smyth Road)

  • Joe Burns

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • Laura Evgin

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • Naomi De Silva

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • Sara Cvancic

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • Terri Robertson

    (Jennerex Inc., 450 Sansome Street, 16th floor)

  • Ji-Eun Je

    (Pusan National University, Jangjeon-dong GeumJeong-gu)

  • Yeon-Sook Lee

    (Pusan National University, Jangjeon-dong GeumJeong-gu)

  • Kelley Parato

    (Ottawa Hospital Research Institute, 501 Smyth Road)

  • Jean-Simon Diallo

    (Ottawa Hospital Research Institute, 501 Smyth Road)

  • Aaron Fenster

    (Robarts Research Institute, 100 Perth Drive, P.O. Box 5015)

  • Manijeh Daneshmand

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • John C. Bell

    (Ottawa Hospital Research Institute, 501 Smyth Road
    University of Ottawa, 75 Laurier Avenue East)

  • David H. Kirn

    (Jennerex Inc., 450 Sansome Street, 16th floor)

Abstract

Oncolytic viruses as cancer therapy Oncolytic viruses, either natural or engineered, preferentially infect and lyse tumour cells. David Kirn and colleagues now report a phase I clinical trial in which they demonstrate systemic delivery of the engineered oncolytic virus JX-594 selectively to tumour tissue after a single injection. Tumour biopsies indicate that the virus replicates in cancer but not in adjacent normal tissue. JX-594 is engineered to replicate in a broad spectrum of cancer cells harbouring activation of the epidermal growth factor receptor/Ras pathway. Although the trial was not designed to demonstrate clinical efficacy, the results suggest that JX-594 may elicit a clinical response in some patients.

Suggested Citation

  • Caroline J. Breitbach & James Burke & Derek Jonker & Joe Stephenson & Andrew R. Haas & Laura Q. M. Chow & Jorge Nieva & Tae-Ho Hwang & Anne Moon & Richard Patt & Adina Pelusio & Fabrice Le Boeuf & Joe, 2011. "Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans," Nature, Nature, vol. 477(7362), pages 99-102, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7362:d:10.1038_nature10358
    DOI: 10.1038/nature10358
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    Cited by:

    1. Jing Lin & Shihui Sun & Kui Zhao & Fei Gao & Renling Wang & Qi Li & Yanlong Zhou & Jing Zhang & Yue Li & Xinyue Wang & Le Du & Shuai Wang & Zi Li & Huijun Lu & Yungang Lan & Deguang Song & Wei Guo & Y, 2023. "Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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