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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Author

Listed:
  • Ryan D. Morin

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Maria Mendez-Lago

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Andrew J. Mungall

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Rodrigo Goya

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Karen L. Mungall

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Richard D. Corbett

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Nathalie A. Johnson

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Tesa M. Severson

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Readman Chiu

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Matthew Field

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Shaun Jackman

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Martin Krzywinski

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • David W. Scott

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Diane L. Trinh

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Jessica Tamura-Wells

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Sa Li

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Marlo R. Firme

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Sanja Rogic

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Malachi Griffith

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Susanna Chan

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Oleksandr Yakovenko

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Irmtraud M. Meyer

    (Centre for High-throughput Biology, Vancouver)

  • Eric Y. Zhao

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Duane Smailus

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Michelle Moksa

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Suganthi Chittaranjan

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Lisa Rimsza

    (University of Arizona)

  • Angela Brooks-Wilson

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
    Simon Fraser University, Burnaby)

  • John J. Spinelli

    (Cancer Control Research, BC Cancer Agency, Vancouver
    School of Population and Public Health, University of British Columbia, Vancouver)

  • Susana Ben-Neriah

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Barbara Meissner

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Bruce Woolcock

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Merrill Boyle

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Helen McDonald

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Angela Tam

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Yongjun Zhao

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Allen Delaney

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Thomas Zeng

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Kane Tse

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Yaron Butterfield

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Inanç Birol

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Rob Holt

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Jacqueline Schein

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Douglas E. Horsman

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Richard Moore

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Steven J. M. Jones

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Joseph M. Connors

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver)

  • Martin Hirst

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver)

  • Randy D. Gascoyne

    (Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
    University of British Columbia, Vancouver)

  • Marco A. Marra

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
    University of British Columbia, Vancouver)

Abstract

Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis.

Suggested Citation

  • Ryan D. Morin & Maria Mendez-Lago & Andrew J. Mungall & Rodrigo Goya & Karen L. Mungall & Richard D. Corbett & Nathalie A. Johnson & Tesa M. Severson & Readman Chiu & Matthew Field & Shaun Jackman & M, 2011. "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma," Nature, Nature, vol. 476(7360), pages 298-303, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7360:d:10.1038_nature10351
    DOI: 10.1038/nature10351
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    Citations

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    Cited by:

    1. Chuanjiang Yu & Qiong Shen & Antony B. Holmes & Tongwei Mo & Anna Tosato & Rajesh Kumar Soni & Clarissa Corinaldesi & Sanjay Koul & Laura Pasqualucci & Shafinaz Hussein & Farhad Forouhar & Riccardo Da, 2024. "MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Longxia Xu & Hongwen Xuan & Wei He & Liang Zhang & Mengying Huang & Kuai Li & Hong Wen & Han Xu & Xiaobing Shi, 2023. "TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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