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Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals

Author

Listed:
  • Clementina Dellomonaco

    (Rice University)

  • James M. Clomburg

    (Rice University)

  • Elliot N. Miller

    (Rice University)

  • Ramon Gonzalez

    (Rice University
    Rice University)

Abstract

Reversing the route to biofuels Biosynthetic pathways that mediate the formation of amino acids, fatty acids and secondary metabolites can be re-engineered to produce complex compounds that show promise as potential biofuels. Dellomonaco et al. show that reversing the direction of the endogenous β-oxidation cycle of fatty acids in Escherichia coli can be used to efficiently synthesize alcohols and carboxylic acids — both potential biofuels — with various chain lengths and functionalities. The β-oxidation cycle is ubiquitous in microbes, so it should be possible to engineer the combinatorial synthesis of non-native products in industrial organisms without recruiting foreign genes.

Suggested Citation

  • Clementina Dellomonaco & James M. Clomburg & Elliot N. Miller & Ramon Gonzalez, 2011. "Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals," Nature, Nature, vol. 476(7360), pages 355-359, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7360:d:10.1038_nature10333
    DOI: 10.1038/nature10333
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    Cited by:

    1. Qiang Yan & William T. Cordell & Michael A. Jindra & Dylan K. Courtney & Madeline K. Kuckuk & Xuanqi Chen & Brian F. Pfleger, 2022. "Metabolic engineering strategies to produce medium-chain oleochemicals via acyl-ACP:CoA transacylase activity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Bastian Vögeli & Luca Schulz & Shivani Garg & Katia Tarasava & James M. Clomburg & Seung Hwan Lee & Aislinn Gonnot & Elamar Hakim Moully & Blaise R. Kimmel & Loan Tran & Hunter Zeleznik & Steven D. Br, 2022. "Cell-free prototyping enables implementation of optimized reverse β-oxidation pathways in heterotrophic and autotrophic bacteria," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Mia Gotovuša & Marko Racar & Lucija Konjević & Jelena Parlov Vuković & Fabio Faraguna, 2023. "The Influence of the Reaction Parameters on the Synthesis of Fatty Acid Octyl Esters and Investigation of Applications Properties of Its Blends with Mineral Diesel," Energies, MDPI, vol. 16(7), pages 1-17, March.
    4. Ulugbek Azimov & Victor Okoro & Hector H. Hernandez, 2021. "Recent Progress and Trends in the Development of Microbial Biofuels from Solid Waste—A Review," Energies, MDPI, vol. 14(19), pages 1-23, September.

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