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Legionella pneumophila SidD is a deAMPylase that modifies Rab1

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  • Yunhao Tan

    (Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA)

  • Zhao-Qing Luo

    (Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA)

Abstract

A pathogen's protein armoury Legionella pneumophila secretes multiple effectors into host cells during infection, some of which modify host trafficking and thereby aid intracellular replication. One of these modifications is AMPylation of Rab1 by L. pneumophila SidM. This study adds another layer to this regulation by demonstrating that a second L. pneumophila effector, SidD, deAMPylates Rab1. The identification of SidD suggests that this pathogen uses a specific set of proteins to hijack the activity of Rab1 for its own purposes.

Suggested Citation

  • Yunhao Tan & Zhao-Qing Luo, 2011. "Legionella pneumophila SidD is a deAMPylase that modifies Rab1," Nature, Nature, vol. 475(7357), pages 506-509, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10307
    DOI: 10.1038/nature10307
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    Cited by:

    1. Jiaqi Fu & Siying Li & Hongxin Guan & Chuang Li & Yan-Bo Zhao & Tao-Tao Chen & Wei Xian & Zhengrui Zhang & Yao Liu & Qingtian Guan & Jingting Wang & Qiuhua Lu & Lina Kang & Si-Ru Zheng & Jinyu Li & Sh, 2024. "Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Jinli Ge & Ying Wang & Xueyu Li & Qian Lu & Hangqian Yu & Hongtao Liu & Kelong Ma & Xuming Deng & Zhao-Qing Luo & Xiaoyun Liu & Jiazhang Qiu, 2024. "Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Yizhi Yuan & Florian M. Stumpf & Lisa A. Schlor & Olivia P. Schmidt & Philip Saumer & Luisa B. Huber & Matthias Frese & Eva Höllmüller & Martin Scheffner & Florian Stengel & Kay Diederichs & Andreas M, 2023. "Chemoproteomic discovery of a human RNA ligase," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Marietta S. Kaspers & Vivian Pogenberg & Christian Pett & Stefan Ernst & Felix Ecker & Philipp Ochtrop & Michael Groll & Christian Hedberg & Aymelt Itzen, 2023. "Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Tobias Sahr & Pedro Escoll & Christophe Rusniok & Sheryl Bui & Gérard Pehau-Arnaudet & Gregory Lavieu & Carmen Buchrieser, 2022. "Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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