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Oxysterols direct immune cell migration via EBI2

Author

Listed:
  • Sébastien Hannedouche

    (Euroscreen S.A.)

  • Juan Zhang

    (Analytical Sciences, Novartis Institutes for BioMedical Research)

  • Tangsheng Yi

    (University of California San Francisco)

  • Weijun Shen

    (Genomics Institute of the Novartis Research Foundation
    The Scripps Research Institute)

  • Deborah Nguyen

    (Genomics Institute of the Novartis Research Foundation)

  • João P. Pereira

    (University of California San Francisco)

  • Danilo Guerini

    (Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research)

  • Birgit U. Baumgarten

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

  • Silvio Roggo

    (Global Discovery Chemistry, Novartis Institutes for BioMedical Research)

  • Ben Wen

    (Genomics Institute of the Novartis Research Foundation)

  • Richard Knochenmuss

    (Analytical Sciences, Novartis Institutes for BioMedical Research)

  • Sophie Noël

    (Euroscreen S.A.)

  • Francois Gessier

    (Global Discovery Chemistry, Novartis Institutes for BioMedical Research)

  • Lisa M. Kelly

    (University of California San Francisco)

  • Mirka Vanek

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

  • Stephane Laurent

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

  • Inga Preuss

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

  • Charlotte Miault

    (Global Discovery Chemistry, Novartis Institutes for BioMedical Research)

  • Isabelle Christen

    (Analytical Sciences, Novartis Institutes for BioMedical Research)

  • Ratna Karuna

    (Analytical Sciences, Novartis Institutes for BioMedical Research)

  • Wei Li

    (Genomics Institute of the Novartis Research Foundation)

  • Dong-In Koo

    (The Scripps Research Institute)

  • Thomas Suply

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

  • Christian Schmedt

    (Genomics Institute of the Novartis Research Foundation)

  • Eric C. Peters

    (Genomics Institute of the Novartis Research Foundation)

  • Rocco Falchetto

    (Analytical Sciences, Novartis Institutes for BioMedical Research)

  • Andreas Katopodis

    (Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research)

  • Carsten Spanka

    (Global Discovery Chemistry, Novartis Institutes for BioMedical Research)

  • Marie-Odile Roy

    (Euroscreen S.A.)

  • Michel Detheux

    (Euroscreen S.A.)

  • Yu Alice Chen

    (Genomics Institute of the Novartis Research Foundation)

  • Peter G. Schultz

    (Genomics Institute of the Novartis Research Foundation)

  • Charles Y. Cho

    (Genomics Institute of the Novartis Research Foundation)

  • Klaus Seuwen

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

  • Jason G. Cyster

    (University of California San Francisco)

  • Andreas W. Sailer

    (Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research)

Abstract

EBI2 receptors revealed as oxysterols The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune disease, and is a critical regulator of the humoral immune response. It is a G-protein-coupled receptor, and its natural ligand has been unknown. Two groups now bring an end to the 'orphan' status of this receptor with identification of specific oxysterols as its natural ligands. The most potent ligand and activator is 7a,25-dihydroxycholesterol, and the EBI2–oxysterol signalling pathway has an important role in the adaptive immune response.

Suggested Citation

  • Sébastien Hannedouche & Juan Zhang & Tangsheng Yi & Weijun Shen & Deborah Nguyen & João P. Pereira & Danilo Guerini & Birgit U. Baumgarten & Silvio Roggo & Ben Wen & Richard Knochenmuss & Sophie Noël , 2011. "Oxysterols direct immune cell migration via EBI2," Nature, Nature, vol. 475(7357), pages 524-527, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10280
    DOI: 10.1038/nature10280
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    Cited by:

    1. Meiling Zheng & Zhi Hu & Xiaole Mei & Lianlian Ouyang & Yang Song & Wenhui Zhou & Yi Kong & Ruifang Wu & Shijia Rao & Hai Long & Wei Shi & Hui Jing & Shuang Lu & Haijing Wu & Sujie Jia & Qianjin Lu & , 2022. "Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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