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A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

Author

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  • Siwanon Jirawatnotai

    (Dana-Farber Cancer Institute, Harvard Medical School
    Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Prathom, 73170 Thailand)

  • Yiduo Hu

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Wojciech Michowski

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Joshua E. Elias

    (Harvard Medical School
    Present addresses: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA (J.E.E.); Institute of Functional Genomics, UMR 5203 CNRS – U 661 INSERM – Université de Montpellier, 34094 Montpellier, France (F.B.).)

  • Lisa Becks

    (Dana-Farber Cancer Institute, Harvard Medical School
    Massachusetts College of Pharmacy and Health Sciences)

  • Frederic Bienvenu

    (Dana-Farber Cancer Institute, Harvard Medical School
    Present addresses: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA (J.E.E.); Institute of Functional Genomics, UMR 5203 CNRS – U 661 INSERM – Université de Montpellier, 34094 Montpellier, France (F.B.).)

  • Agnieszka Zagozdzon

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Tapasree Goswami

    (Harvard Medical School)

  • Yaoyu E. Wang

    (Center for Cancer Computational Biology, Dana-Farber Cancer Institute)

  • Alan B. Clark

    (Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health)

  • Thomas A. Kunkel

    (Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health)

  • Tanja van Harn

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Bing Xia

    (The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School)

  • Mick Correll

    (Center for Cancer Computational Biology, Dana-Farber Cancer Institute)

  • John Quackenbush

    (Center for Cancer Computational Biology, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute, and Harvard School of Public Health)

  • David M. Livingston

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Steven P. Gygi

    (Harvard Medical School)

  • Piotr Sicinski

    (Dana-Farber Cancer Institute, Harvard Medical School)

Abstract

Cyclin D1 role in DNA repair Cyclin D1 has a crucial role in the cell cycle and is often overexpressed in cancer. Piotr Sicinski and colleagues report an unexpected function for cyclin D1 in DNA repair that is independent of its known CDK-dependent role. Cyclin D1 is recruited to sites of DNA damage and binds to RAD51, a key DNA recombinase that drives the homologous recombination process. This function for cyclin D1 also operates in retinoblastoma protein (pRB)-negative human cancer, suggesting that targeting cyclin D1 may be beneficial in this condition.

Suggested Citation

  • Siwanon Jirawatnotai & Yiduo Hu & Wojciech Michowski & Joshua E. Elias & Lisa Becks & Frederic Bienvenu & Agnieszka Zagozdzon & Tapasree Goswami & Yaoyu E. Wang & Alan B. Clark & Thomas A. Kunkel & Ta, 2011. "A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers," Nature, Nature, vol. 474(7350), pages 230-234, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7350:d:10.1038_nature10155
    DOI: 10.1038/nature10155
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    Cited by:

    1. Noreddine Benkerroum, 2020. "Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action," IJERPH, MDPI, vol. 17(2), pages 1-28, January.

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