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Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

Author

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  • Yongfang Zhao

    (Center for Molecular Recognition, Columbia University College of Physicians and Surgeons
    Columbia University College of Physicians and Surgeons
    New York State Psychiatric Institute, 1051 Riverside Drive)

  • Daniel S. Terry

    (Weill Medical College of Cornell University)

  • Lei Shi

    (Weill Medical College of Cornell University
    HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, Cornell University)

  • Matthias Quick

    (Center for Molecular Recognition, Columbia University College of Physicians and Surgeons
    Columbia University College of Physicians and Surgeons
    New York State Psychiatric Institute, 1051 Riverside Drive)

  • Harel Weinstein

    (Weill Medical College of Cornell University
    HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, Cornell University)

  • Scott C. Blanchard

    (Weill Medical College of Cornell University)

  • Jonathan A. Javitch

    (Center for Molecular Recognition, Columbia University College of Physicians and Surgeons
    Columbia University College of Physicians and Surgeons
    Columbia University College of Physicians and Surgeons
    New York State Psychiatric Institute, 1051 Riverside Drive)

Abstract

An open gate to neurotransmitters Neurotransmitters are removed from the synapse by neurotransmitter/Na+ symporters (NSSs) in a reuptake process driven by the Na+ gradient. Zhao et al. examined the coupling of substrate binding to structural transitions in the prokaryotic NSS homologue LeuT. Using single-molecule fluorescence resonance energy transfer, functional experiments and computational studies, they find that LeuT facilitates intracellular gate opening and substrate release at the intracellular face of the protein.

Suggested Citation

  • Yongfang Zhao & Daniel S. Terry & Lei Shi & Matthias Quick & Harel Weinstein & Scott C. Blanchard & Jonathan A. Javitch, 2011. "Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue," Nature, Nature, vol. 474(7349), pages 109-113, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7349:d:10.1038_nature09971
    DOI: 10.1038/nature09971
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    Cited by:

    1. Paul David Harris & Alessandra Narducci & Christian Gebhardt & Thorben Cordes & Shimon Weiss & Eitan Lerner, 2022. "Multi-parameter photon-by-photon hidden Markov modeling," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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