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Catalysis for fluorination and trifluoromethylation

Author

Listed:
  • Takeru Furuya

    (Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Present address: SciFluor Life Sciences LLC, 33 Arch Street, Suite 3201, Boston, Massachusetts 02110, USA.)

  • Adam S. Kamlet

    (Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Tobias Ritter

    (Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA)

Abstract

Fluorination to the fore When incorporated into organic compounds, fluorine atoms often impart useful properties. For example, fluorination improves the thermal stability of some materials, and enhances the metabolic stability of some pharmaceuticals. Recent advances make it possible to create carbon–fluorine bonds at specific positions in complex organic molecules, paving the way for a new and potentially productive era in fluorination chemistry. In this Review, Furuya et al. describe the inherent challenges associated with carbon–fluorine bond-formation reactions, discuss the breakthroughs that have helped to overcome these problems and outline the likely direction of future research.

Suggested Citation

  • Takeru Furuya & Adam S. Kamlet & Tobias Ritter, 2011. "Catalysis for fluorination and trifluoromethylation," Nature, Nature, vol. 473(7348), pages 470-477, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7348:d:10.1038_nature10108
    DOI: 10.1038/nature10108
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    Cited by:

    1. Ningning Li & Bingjing Hu & Anming Wang & Huimin Li & Youcheng Yin & Tianyu Mao & Tian Xie, 2020. "Facile Bioinspired Preparation of Fluorinase@Fluoridated Hydroxyapatite Nanoflowers for the Biosynthesis of 5′-Fluorodeoxy Adenosine," Sustainability, MDPI, vol. 12(1), pages 1-15, January.

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