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Molecular mechanisms and clinical applications of angiogenesis

Author

Listed:
  • Peter Carmeliet

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K. U. Leuven)

  • Rakesh K. Jain

    (Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital and Harvard Medical School)

Abstract

Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms of angiogenesis (blood vessel growth) has increased at an explosive rate and has led to the approval of anti-angiogenic drugs for cancer and eye diseases. So far, hundreds of thousands of patients have benefited from blockers of the angiogenic protein vascular endothelial growth factor, but limited efficacy and resistance remain outstanding problems. Recent preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.

Suggested Citation

  • Peter Carmeliet & Rakesh K. Jain, 2011. "Molecular mechanisms and clinical applications of angiogenesis," Nature, Nature, vol. 473(7347), pages 298-307, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature10144
    DOI: 10.1038/nature10144
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