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Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Author

Listed:
  • Amar Sahay

    (Columbia University
    The New York State Psychiatric Institute)

  • Kimberly N. Scobie

    (Columbia University
    The New York State Psychiatric Institute)

  • Alexis S. Hill

    (Columbia University
    The New York State Psychiatric Institute)

  • Colin M. O'Carroll

    (Columbia University
    The New York State Psychiatric Institute)

  • Mazen A. Kheirbek

    (Columbia University
    The New York State Psychiatric Institute)

  • Nesha S. Burghardt

    (Columbia University
    The New York State Psychiatric Institute)

  • André A. Fenton

    (The Robert F. Furchgott Center for Neural and Behavioural Science, State University of New York, Downstate Medical Center)

  • Alex Dranovsky

    (Columbia University
    The New York State Psychiatric Institute)

  • René Hen

    (Columbia University
    The New York State Psychiatric Institute
    Columbia University)

Abstract

Neurogenesis and antidepressants Loss-of-function studies have implicated adult-born hippocampal neurons — as opposed to those present at birth — in learning and memory and in mediating some effects of antidepressants. Experiments using an inducible genetic gain-of-function strategy to augment the survival of adult-born neurons in mice demonstrate a causal link between increased adult hippocampal neurogenesis and enhancement of specific cognitive functions. This raises the possibility that anxiety disorders and memory impairment might be treated by stimulating adult hippocampal neurogenesis.

Suggested Citation

  • Amar Sahay & Kimberly N. Scobie & Alexis S. Hill & Colin M. O'Carroll & Mazen A. Kheirbek & Nesha S. Burghardt & André A. Fenton & Alex Dranovsky & René Hen, 2011. "Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation," Nature, Nature, vol. 472(7344), pages 466-470, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature09817
    DOI: 10.1038/nature09817
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    Cited by:

    1. Nicola Forte & Serena Boccella & Lea Tunisi & Alba Clara Fernández-Rilo & Roberta Imperatore & Fabio Arturo Iannotti & Maria Risi & Monica Iannotta & Fabiana Piscitelli & Raffaele Capasso & Paolo Giro, 2021. "Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Bao-Fei Sun & Qing-Qing Wang & Zi-Jiang Yu & Yan Yu & Chao-Lun Xiao & Chao-Sheng Kang & Guo Ge & Yan Linghu & Jun-De Zhu & Yu-Mei Li & Qiang-Ming Li & Shi-Peng Luo & Dang Yang & Lin Li & Wen-Yan Zhang, 2015. "Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-15, September.
    3. Mégane Missaire & Nicolas Fraize & Mickaël Antoine Joseph & Al Mahdy Hamieh & Régis Parmentier & Aline Marighetto & Paul Antoine Salin & Gaël Malleret, 2017. "Long-term effects of interference on short-term memory performance in the rat," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-18, March.
    4. M. Agustina Frechou & Sunaina S. Martin & Kelsey D. McDermott & Evan A. Huaman & Şölen Gökhan & Wolfgang A. Tomé & Ruben Coen-Cagli & J. Tiago Gonçalves, 2024. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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