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TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Author

Listed:
  • Thomas Pertel

    (University of Geneva)

  • Stéphane Hausmann

    (University of Geneva)

  • Damien Morger

    (University of Zurich)

  • Sara Züger

    (University of Zurich)

  • Jessica Guerra

    (University of Geneva)

  • Josefina Lascano

    (University of Geneva)

  • Christian Reinhard

    (University of Geneva)

  • Federico A. Santoni

    (University of Geneva)

  • Pradeep D. Uchil

    (Section of Microbial Pathogenesis, Yale University School of Medicine)

  • Laurence Chatel

    (Novimmune SA)

  • Aurélie Bisiaux

    (Institut Pasteur, Inserm U818)

  • Matthew L. Albert

    (Institut Pasteur, Inserm U818)

  • Caterina Strambio-De-Castillia

    (University of Geneva)

  • Walther Mothes

    (Section of Microbial Pathogenesis, Yale University School of Medicine)

  • Massimo Pizzato

    (University of Geneva)

  • Markus G. Grütter

    (University of Zurich)

  • Jeremy Luban

    (University of Geneva)

Abstract

Multi-layered antiviral activity of TRIM5 TRIM5 is an E3 ubiquitin ligase with known antiretroviral restriction factor activity, although the mechanisms involved are poorly understood. Luban and colleagues now demonstrate that TRIM5 activates innate immune signalling pathways and acts as a pattern recognition receptor specific for the retrovirus capsid lattice.

Suggested Citation

  • Thomas Pertel & Stéphane Hausmann & Damien Morger & Sara Züger & Jessica Guerra & Josefina Lascano & Christian Reinhard & Federico A. Santoni & Pradeep D. Uchil & Laurence Chatel & Aurélie Bisiaux & M, 2011. "TRIM5 is an innate immune sensor for the retrovirus capsid lattice," Nature, Nature, vol. 472(7343), pages 361-365, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09976
    DOI: 10.1038/nature09976
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    Cited by:

    1. Frank Herkules & Corey H. Yu & Alexander B. Taylor & Vi Dougherty & Susan T. Weintraub & Dmitri N. Ivanov, 2022. "Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Leo Kiss & Tyler Rhinesmith & Jakub Luptak & Claire F. Dickson & Jonas Weidenhausen & Shannon Smyly & Ji-Chun Yang & Sarah L. Maslen & Irmgard Sinning & David Neuhaus & Dean Clift & Leo C. James, 2023. "Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Xiang-Hong Ran & Jia-Wu Zhu & Run-Ze Ni & Yong-Tang Zheng & Ya-Yun Chen & Wei-Hua Zheng & Dan Mu, 2023. "TRIM5α recruits HDAC1 to p50 and Sp1 and promotes H3K9 deacetylation at the HIV-1 LTR," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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