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Metabolic trade-offs and the maintenance of the fittest and the flattest

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  • Robert E. Beardmore

    (Imperial College London, Huxley Building, 180 Queen’s Gate, London SW7 2A7, UK
    Present address: Biosciences, Geoffrey Pope Building, Streatham Campus, University of Exeter, Exeter, Devon, EX4 4SB, UK.)

  • Ivana Gudelj

    (Imperial College London, Huxley Building, 180 Queen’s Gate, London SW7 2A7, UK
    Present address: Biosciences, Geoffrey Pope Building, Streatham Campus, University of Exeter, Exeter, Devon, EX4 4SB, UK.)

  • David A. Lipson

    (San Diego State University)

  • Laurence D. Hurst

    (University of Bath, Claverton Down, Bath, BA2 7AY, UK)

Abstract

The maintenance of diversity Environmental heterogeneity is considered an important factor in the maintenance of species diversity. Yet diversity is also maintained in some homogeneous environments. Ecological theory has struggled, in particular, to account for the diversity of metabolic strategies found in seemingly homogeneous populations of microbes grown in chemostats. An explanation that fits the experimental data is now offered: at realistic mutation rates there is coexistence between fit genotypes that have unfit neighbours on the adaptive landscape, and less fit but more mutationally robust (sometimes called 'flat') genotypes.

Suggested Citation

  • Robert E. Beardmore & Ivana Gudelj & David A. Lipson & Laurence D. Hurst, 2011. "Metabolic trade-offs and the maintenance of the fittest and the flattest," Nature, Nature, vol. 472(7343), pages 342-346, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09905
    DOI: 10.1038/nature09905
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    Cited by:

    1. Ivana Gudelj & Margie Kinnersley & Peter Rashkov & Karen Schmidt & Frank Rosenzweig, 2016. "Stability of Cross-Feeding Polymorphisms in Microbial Communities," PLOS Computational Biology, Public Library of Science, vol. 12(12), pages 1-17, December.
    2. González Casanova, Adrián & Miró Pina, Verónica & Pardo, Juan Carlos, 2020. "The Wright–Fisher model with efficiency," Theoretical Population Biology, Elsevier, vol. 132(C), pages 33-46.
    3. Olga A Nev & Richard J Lindsay & Alys Jepson & Lisa Butt & Robert E Beardmore & Ivana Gudelj, 2021. "Predicting microbial growth dynamics in response to nutrient availability," PLOS Computational Biology, Public Library of Science, vol. 17(3), pages 1-20, March.
    4. Wei Fan & Jingchao Yuan & Jinggui Wu & Hongguang Cai, 2023. "Effects of Straw Maize on the Bacterial Community and Carbon Stability at Different Soil Depths," Agriculture, MDPI, vol. 13(7), pages 1-15, June.

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