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Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Author

Listed:
  • Bo Li

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego
    Cold Spring Harbor Laboratory, 1 Bungtown Road)

  • Joaquin Piriz

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

  • Martine Mirrione

    (Cold Spring Harbor Laboratory, 1 Bungtown Road
    Brookhaven National Laboratory)

  • ChiHye Chung

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

  • Christophe D. Proulx

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

  • Daniela Schulz

    (Brookhaven National Laboratory)

  • Fritz Henn

    (Cold Spring Harbor Laboratory, 1 Bungtown Road
    Brookhaven National Laboratory)

  • Roberto Malinow

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

Abstract

Synaptic potentiation in depression It has recently been shown that neurons in the lateral habenula (LHb), a nucleus that projects to midbrain reward areas, can signal negative reward or 'disappointment' by modulating a dopaminergic centre, and may be disrupted in depressive disorders. Experiments in rats exhibiting learned helplessness (a model of major depression) now show that excitatory synapses onto LHb neurons are potentiated, and that this correlates with helplessness behaviour. Depleting transmitter release by repeated electrical stimulation of the LHb using a protocol similar to deep brain stimulation rescues both synaptic changes and learned helplessness behaviour. These results point to a mechanism by which deep brain stimulation in LHb could be effective in treating depression.

Suggested Citation

  • Bo Li & Joaquin Piriz & Martine Mirrione & ChiHye Chung & Christophe D. Proulx & Daniela Schulz & Fritz Henn & Roberto Malinow, 2011. "Synaptic potentiation onto habenula neurons in the learned helplessness model of depression," Nature, Nature, vol. 470(7335), pages 535-539, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09742
    DOI: 10.1038/nature09742
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    Cited by:

    1. Anton Ilango & Jason Shumake & Wolfram Wetzel & Henning Scheich & Frank W Ohl, 2013. "Electrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Response," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    2. Maggie W. Waung & Kayla A. Maanum & Thomas J. Cirino & Joseph R. Driscoll & Chris O’Brien & Svetlana Bryant & Kasra A. Mansourian & Marisela Morales & David J. Barker & Elyssa B. Margolis, 2022. "A diencephalic circuit in rats for opioid analgesia but not positive reinforcement," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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