IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v470y2011i7335d10.1038_nature09742.html
   My bibliography  Save this article

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Author

Listed:
  • Bo Li

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego
    Cold Spring Harbor Laboratory, 1 Bungtown Road)

  • Joaquin Piriz

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

  • Martine Mirrione

    (Cold Spring Harbor Laboratory, 1 Bungtown Road
    Brookhaven National Laboratory)

  • ChiHye Chung

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

  • Christophe D. Proulx

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

  • Daniela Schulz

    (Brookhaven National Laboratory)

  • Fritz Henn

    (Cold Spring Harbor Laboratory, 1 Bungtown Road
    Brookhaven National Laboratory)

  • Roberto Malinow

    (Center for Neural Circuits and Behavior, 9500 Gilman Drive # 0634, University of California at San Diego)

Abstract

Synaptic potentiation in depression It has recently been shown that neurons in the lateral habenula (LHb), a nucleus that projects to midbrain reward areas, can signal negative reward or 'disappointment' by modulating a dopaminergic centre, and may be disrupted in depressive disorders. Experiments in rats exhibiting learned helplessness (a model of major depression) now show that excitatory synapses onto LHb neurons are potentiated, and that this correlates with helplessness behaviour. Depleting transmitter release by repeated electrical stimulation of the LHb using a protocol similar to deep brain stimulation rescues both synaptic changes and learned helplessness behaviour. These results point to a mechanism by which deep brain stimulation in LHb could be effective in treating depression.

Suggested Citation

  • Bo Li & Joaquin Piriz & Martine Mirrione & ChiHye Chung & Christophe D. Proulx & Daniela Schulz & Fritz Henn & Roberto Malinow, 2011. "Synaptic potentiation onto habenula neurons in the learned helplessness model of depression," Nature, Nature, vol. 470(7335), pages 535-539, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09742
    DOI: 10.1038/nature09742
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09742
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09742?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maggie W. Waung & Kayla A. Maanum & Thomas J. Cirino & Joseph R. Driscoll & Chris O’Brien & Svetlana Bryant & Kasra A. Mansourian & Marisela Morales & David J. Barker & Elyssa B. Margolis, 2022. "A diencephalic circuit in rats for opioid analgesia but not positive reinforcement," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Anton Ilango & Jason Shumake & Wolfram Wetzel & Henning Scheich & Frank W Ohl, 2013. "Electrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Response," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09742. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.