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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

Author

Listed:
  • Wei Tan

    (Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA
    Present address: Pfizer Oncology Research Unit West, San Diego, California 92121, USA.)

  • Weizhou Zhang

    (Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA)

  • Amy Strasner

    (Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA)

  • Sergei Grivennikov

    (Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA)

  • Jin Q. Cheng

    (H. Lee Moffitt Cancer Center)

  • Robert M. Hoffman

    (University of California San Diego
    AntiCancer Inc.)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA)

Abstract

Metastasis in breast cancer In a mouse model of ErbB-driven mammary tumours, Tan et al. find a role for RANKL (receptor activator of nuclear factor-κB ligand) in the formation of lung metastases. RANKL is produced by regulatory T cells infiltrating the primary tumours, and acts through its receptor RANK, which is expressed on the cancer cells. Targeting RANKL may therefore prove useful in reducing breast cancer metastases.

Suggested Citation

  • Wei Tan & Weizhou Zhang & Amy Strasner & Sergei Grivennikov & Jin Q. Cheng & Robert M. Hoffman & Michael Karin, 2011. "Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling," Nature, Nature, vol. 470(7335), pages 548-553, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09707
    DOI: 10.1038/nature09707
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    Cited by:

    1. Tsion Zewdu Minas & Julián Candia & Tiffany H. Dorsey & Francine Baker & Wei Tang & Maeve Kiely & Cheryl J. Smith & Amy L. Zhang & Symone V. Jordan & Obadi M. Obadi & Anuoluwapo Ajao & Yao Tettey & Ri, 2022. "Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Athina Varveri & Miranta Papadopoulou & Zacharias Papadovasilakis & Ewoud B. Compeer & Aigli-Ioanna Legaki & Anastasios Delis & Vasileia Damaskou & Louis Boon & Sevasti Papadogiorgaki & Martina Samiot, 2024. "Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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