IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-29235-2.html
   My bibliography  Save this article

Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer

Author

Listed:
  • Tsion Zewdu Minas

    (National Cancer Institute, National Institutes of Health)

  • Julián Candia

    (National Cancer Institute, National Institutes of Health
    National Institute on Aging, National Institutes of Health)

  • Tiffany H. Dorsey

    (National Cancer Institute, National Institutes of Health)

  • Francine Baker

    (National Cancer Institute, National Institutes of Health)

  • Wei Tang

    (National Cancer Institute, National Institutes of Health)

  • Maeve Kiely

    (National Cancer Institute, National Institutes of Health)

  • Cheryl J. Smith

    (National Cancer Institute, National Institutes of Health)

  • Amy L. Zhang

    (National Cancer Institute, National Institutes of Health)

  • Symone V. Jordan

    (National Cancer Institute, National Institutes of Health)

  • Obadi M. Obadi

    (National Cancer Institute, National Institutes of Health)

  • Anuoluwapo Ajao

    (National Cancer Institute, National Institutes of Health)

  • Yao Tettey

    (University of Ghana Medical School)

  • Richard B. Biritwum

    (University of Ghana Medical School)

  • Andrew A. Adjei

    (University of Ghana Medical School)

  • James E. Mensah

    (University of Ghana Medical School)

  • Robert N. Hoover

    (National Cancer Institute, National Institutes of Health)

  • Frank J. Jenkins

    (Hillman Cancer Center, University of Pittsburgh)

  • Rick Kittles

    (City of Hope Comprehensive Cancer Center)

  • Ann W. Hsing

    (Stanford Cancer Institute, Stanford School of Medicine
    Stanford Prevention Research Center, Stanford School of Medicine)

  • Xin W. Wang

    (National Cancer Institute, National Institutes of Health
    National Cancer Institute, National Institutes of Health)

  • Christopher A. Loffredo

    (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center)

  • Clayton Yates

    (Tuskegee University)

  • Michael B. Cook

    (National Cancer Institute, National Institutes of Health)

  • Stefan Ambs

    (National Cancer Institute, National Institutes of Health)

Abstract

There is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of African descent harbor a unique systemic immune-oncological signature and measure 82 circulating proteins in almost 3000 Ghanaian, African American, and European American men. Protein signatures for suppression of tumor immunity and chemotaxis are elevated in men of West African ancestry. Importantly, the suppression of tumor immunity protein signature associates with metastatic and lethal prostate cancer, pointing to clinical importance. Moreover, two markers, pleiotrophin and TNFRSF9, predict poor disease survival specifically among African American men. These findings indicate that immune-oncology marker profiles differ between men of African and European descent. These differences may contribute to the disproportionate burden of lethal prostate cancer in men of African ancestry. The elevated peripheral suppression of tumor immunity may have important implication for guidance of cancer therapy which could particularly benefit African American patients.

Suggested Citation

  • Tsion Zewdu Minas & Julián Candia & Tiffany H. Dorsey & Francine Baker & Wei Tang & Maeve Kiely & Cheryl J. Smith & Amy L. Zhang & Symone V. Jordan & Obadi M. Obadi & Anuoluwapo Ajao & Yao Tettey & Ri, 2022. "Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29235-2
    DOI: 10.1038/s41467-022-29235-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-29235-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-29235-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Wei Tan & Weizhou Zhang & Amy Strasner & Sergei Grivennikov & Jin Q. Cheng & Robert M. Hoffman & Michael Karin, 2011. "Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling," Nature, Nature, vol. 470(7335), pages 548-553, February.
    2. Maxime Rotival & Hélène Quach & Lluis Quintana-Murci, 2019. "Defining the genetic and evolutionary architecture of alternative splicing in response to infection," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tsion Zewdu Minas & Brittany D. Lord & Amy L. Zhang & Julián Candia & Tiffany H. Dorsey & Francine S. Baker & Wei Tang & Maeve Bailey-Whyte & Cheryl J. Smith & Obadi M. Obadi & Anuoluwapo Ajao & Symon, 2023. "Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kensuke Yamaguchi & Kazuyoshi Ishigaki & Akari Suzuki & Yumi Tsuchida & Haruka Tsuchiya & Shuji Sumitomo & Yasuo Nagafuchi & Fuyuki Miya & Tatsuhiko Tsunoda & Hirofumi Shoda & Keishi Fujio & Kazuhiko , 2022. "Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29235-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.