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Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer

Author

Listed:
  • Tsion Zewdu Minas

    (National Cancer Institute, National Institutes of Health)

  • Julián Candia

    (National Cancer Institute, National Institutes of Health
    National Institute on Aging, National Institutes of Health)

  • Tiffany H. Dorsey

    (National Cancer Institute, National Institutes of Health)

  • Francine Baker

    (National Cancer Institute, National Institutes of Health)

  • Wei Tang

    (National Cancer Institute, National Institutes of Health)

  • Maeve Kiely

    (National Cancer Institute, National Institutes of Health)

  • Cheryl J. Smith

    (National Cancer Institute, National Institutes of Health)

  • Amy L. Zhang

    (National Cancer Institute, National Institutes of Health)

  • Symone V. Jordan

    (National Cancer Institute, National Institutes of Health)

  • Obadi M. Obadi

    (National Cancer Institute, National Institutes of Health)

  • Anuoluwapo Ajao

    (National Cancer Institute, National Institutes of Health)

  • Yao Tettey

    (University of Ghana Medical School)

  • Richard B. Biritwum

    (University of Ghana Medical School)

  • Andrew A. Adjei

    (University of Ghana Medical School)

  • James E. Mensah

    (University of Ghana Medical School)

  • Robert N. Hoover

    (National Cancer Institute, National Institutes of Health)

  • Frank J. Jenkins

    (Hillman Cancer Center, University of Pittsburgh)

  • Rick Kittles

    (City of Hope Comprehensive Cancer Center)

  • Ann W. Hsing

    (Stanford Cancer Institute, Stanford School of Medicine
    Stanford Prevention Research Center, Stanford School of Medicine)

  • Xin W. Wang

    (National Cancer Institute, National Institutes of Health
    National Cancer Institute, National Institutes of Health)

  • Christopher A. Loffredo

    (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center)

  • Clayton Yates

    (Tuskegee University)

  • Michael B. Cook

    (National Cancer Institute, National Institutes of Health)

  • Stefan Ambs

    (National Cancer Institute, National Institutes of Health)

Abstract

There is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of African descent harbor a unique systemic immune-oncological signature and measure 82 circulating proteins in almost 3000 Ghanaian, African American, and European American men. Protein signatures for suppression of tumor immunity and chemotaxis are elevated in men of West African ancestry. Importantly, the suppression of tumor immunity protein signature associates with metastatic and lethal prostate cancer, pointing to clinical importance. Moreover, two markers, pleiotrophin and TNFRSF9, predict poor disease survival specifically among African American men. These findings indicate that immune-oncology marker profiles differ between men of African and European descent. These differences may contribute to the disproportionate burden of lethal prostate cancer in men of African ancestry. The elevated peripheral suppression of tumor immunity may have important implication for guidance of cancer therapy which could particularly benefit African American patients.

Suggested Citation

  • Tsion Zewdu Minas & Julián Candia & Tiffany H. Dorsey & Francine Baker & Wei Tang & Maeve Kiely & Cheryl J. Smith & Amy L. Zhang & Symone V. Jordan & Obadi M. Obadi & Anuoluwapo Ajao & Yao Tettey & Ri, 2022. "Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29235-2
    DOI: 10.1038/s41467-022-29235-2
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    References listed on IDEAS

    as
    1. Wei Tan & Weizhou Zhang & Amy Strasner & Sergei Grivennikov & Jin Q. Cheng & Robert M. Hoffman & Michael Karin, 2011. "Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling," Nature, Nature, vol. 470(7335), pages 548-553, February.
    2. Maxime Rotival & Hélène Quach & Lluis Quintana-Murci, 2019. "Defining the genetic and evolutionary architecture of alternative splicing in response to infection," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
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    Cited by:

    1. Tsion Zewdu Minas & Brittany D. Lord & Amy L. Zhang & Julián Candia & Tiffany H. Dorsey & Francine S. Baker & Wei Tang & Maeve Bailey-Whyte & Cheryl J. Smith & Obadi M. Obadi & Anuoluwapo Ajao & Symon, 2023. "Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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