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Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

Author

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  • Martin P. Stewart

    (ETH Zürich, CH-4058 Basel, Switzerland
    Biotechnology Center, University of Technology Dresden, D-01307 Dresden, Germany)

  • Jonne Helenius

    (ETH Zürich, CH-4058 Basel, Switzerland)

  • Yusuke Toyoda

    (Max-Planck-Institute of Molecular Cell Biology and Genetics, D-1307 Dresden, Germany)

  • Subramanian P. Ramanathan

    (ETH Zürich, CH-4058 Basel, Switzerland)

  • Daniel J. Muller

    (ETH Zürich, CH-4058 Basel, Switzerland)

  • Anthony A. Hyman

    (Max-Planck-Institute of Molecular Cell Biology and Genetics, D-1307 Dresden, Germany)

Abstract

What makes cells go round Forces that drive cell shape changes are fundamental to development. During mitosis, adherent cells change from a flattened to rounded morphology, and this is thought to be necessary for the geometric requirements of cell division. Stewart et al. study the forces that drive this shape change. They find that the mitotic rounding force depends both on the actomyosin cytoskeleton and the cell's ability to regulate osmolarity. The rounding force is generated by osmotic pressure, and the actomyosin cortex maintains this rounding pressure against external forces. These results support the idea that in animal cells, the actomyosin cortex behaves as an internal cell wall, directing osmotic expansion to control cell shape.

Suggested Citation

  • Martin P. Stewart & Jonne Helenius & Yusuke Toyoda & Subramanian P. Ramanathan & Daniel J. Muller & Anthony A. Hyman, 2011. "Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding," Nature, Nature, vol. 469(7329), pages 226-230, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09642
    DOI: 10.1038/nature09642
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    Cited by:

    1. Sophie Herzog & Gotthold Fläschner & Ilaria Incaviglia & Javier Casares Arias & Aaron Ponti & Nico Strohmeyer & Michele M. Nava & Daniel J. Müller, 2024. "Monitoring the mass, eigenfrequency, and quality factor of mammalian cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Ryota Sakamoto & Michael P. Murrell, 2024. "Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Maximilian Huber & Javier Casares-Arias & Reinhard Fässler & Daniel J. Müller & Nico Strohmeyer, 2023. "In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Antoine Vian & Marie Pochitaloff & Shuo-Ting Yen & Sangwoo Kim & Jennifer Pollock & Yucen Liu & Ellen M. Sletten & Otger Campàs, 2023. "In situ quantification of osmotic pressure within living embryonic tissues," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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