IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v469y2011i7329d10.1038_nature09642.html
   My bibliography  Save this article

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

Author

Listed:
  • Martin P. Stewart

    (ETH Zürich, CH-4058 Basel, Switzerland
    Biotechnology Center, University of Technology Dresden, D-01307 Dresden, Germany)

  • Jonne Helenius

    (ETH Zürich, CH-4058 Basel, Switzerland)

  • Yusuke Toyoda

    (Max-Planck-Institute of Molecular Cell Biology and Genetics, D-1307 Dresden, Germany)

  • Subramanian P. Ramanathan

    (ETH Zürich, CH-4058 Basel, Switzerland)

  • Daniel J. Muller

    (ETH Zürich, CH-4058 Basel, Switzerland)

  • Anthony A. Hyman

    (Max-Planck-Institute of Molecular Cell Biology and Genetics, D-1307 Dresden, Germany)

Abstract

What makes cells go round Forces that drive cell shape changes are fundamental to development. During mitosis, adherent cells change from a flattened to rounded morphology, and this is thought to be necessary for the geometric requirements of cell division. Stewart et al. study the forces that drive this shape change. They find that the mitotic rounding force depends both on the actomyosin cytoskeleton and the cell's ability to regulate osmolarity. The rounding force is generated by osmotic pressure, and the actomyosin cortex maintains this rounding pressure against external forces. These results support the idea that in animal cells, the actomyosin cortex behaves as an internal cell wall, directing osmotic expansion to control cell shape.

Suggested Citation

  • Martin P. Stewart & Jonne Helenius & Yusuke Toyoda & Subramanian P. Ramanathan & Daniel J. Muller & Anthony A. Hyman, 2011. "Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding," Nature, Nature, vol. 469(7329), pages 226-230, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09642
    DOI: 10.1038/nature09642
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09642
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09642?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sophie Herzog & Gotthold Fläschner & Ilaria Incaviglia & Javier Casares Arias & Aaron Ponti & Nico Strohmeyer & Michele M. Nava & Daniel J. Müller, 2024. "Monitoring the mass, eigenfrequency, and quality factor of mammalian cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Maximilian Huber & Javier Casares-Arias & Reinhard Fässler & Daniel J. Müller & Nico Strohmeyer, 2023. "In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Antoine Vian & Marie Pochitaloff & Shuo-Ting Yen & Sangwoo Kim & Jennifer Pollock & Yucen Liu & Ellen M. Sletten & Otger Campàs, 2023. "In situ quantification of osmotic pressure within living embryonic tissues," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09642. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.