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Subtypes of medulloblastoma have distinct developmental origins

Author

Listed:
  • Paul Gibson

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Yiai Tong

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Giles Robinson

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place
    St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Margaret C. Thompson

    (The Cleveland Clinic)

  • D. Spencer Currle

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Christopher Eden

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Tanya A. Kranenburg

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Twala Hogg

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Helen Poppleton

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Julie Martin

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • David Finkelstein

    (Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Stanley Pounds

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Aaron Weiss

    (Robert Wood Johnson Medical School)

  • Zoltan Patay

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Matthew Scoggins

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Robert Ogg

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Yanxin Pei

    (Duke University Medical Center)

  • Zeng-Jie Yang

    (Duke University Medical Center)

  • Sonja Brun

    (Duke University Medical Center)

  • Youngsoo Lee

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Frederique Zindy

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Janet C. Lindsey

    (Northern Institute for Cancer Research, Newcastle University)

  • Makoto M. Taketo

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo, Kyoto 606-8501, Japan)

  • Frederick A. Boop

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Robert A. Sanford

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Amar Gajjar

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Steven C. Clifford

    (Northern Institute for Cancer Research, Newcastle University)

  • Martine F. Roussel

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Peter J. McKinnon

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • David H. Gutmann

    (Washington University School of Medicine)

  • David W. Ellison

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place)

  • Robert Wechsler-Reya

    (Duke University Medical Center)

  • Richard J. Gilbertson

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place
    St Jude Children’s Research Hospital, 262 Danny Thomas Place)

Abstract

Medulloblastoma subtypes identified Medulloblastomas, a common type of malignant childhood brain tumour, are thought in the main to arise from the cerebellum, many of them involving aberrant signalling of a signalling pathway involving Sonic Hedgehog. There is substantial heterogeneity among medulloblastomas, however, and new work shows that a distinct subtype of medulloblastoma arises from the dorsal brainstem and is associated with altered Wnt signalling. Distinct molecular and clinical profiles of the subtypes have implications for future treatment. This suggests that subgroups of medulloblastoma are intrinsically different diseases, so therapeutic strategies may need to be tailored accordingly.

Suggested Citation

  • Paul Gibson & Yiai Tong & Giles Robinson & Margaret C. Thompson & D. Spencer Currle & Christopher Eden & Tanya A. Kranenburg & Twala Hogg & Helen Poppleton & Julie Martin & David Finkelstein & Stanley, 2010. "Subtypes of medulloblastoma have distinct developmental origins," Nature, Nature, vol. 468(7327), pages 1095-1099, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09587
    DOI: 10.1038/nature09587
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    Citations

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    Cited by:

    1. Xi Lu & Naga Prathyusha Maturi & Malin Jarvius & Irem Yildirim & Yonglong Dang & Linxuan Zhao & Yuan Xie & E-Jean Tan & Pengwei Xing & Rolf Larsson & Mårten Fryknäs & Lene Uhrbom & Xingqi Chen, 2022. "Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Melanie Schoof & Shweta Godbole & Thomas K. Albert & Matthias Dottermusch & Carolin Walter & Annika Ballast & Nan Qin & Marlena Baca Olivera & Carolin Göbel & Sina Neyazi & Dörthe Holdhof & Catena Kre, 2023. "Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. David R. Ghasemi & Konstantin Okonechnikov & Anne Rademacher & Stephan Tirier & Kendra K. Maass & Hanna Schumacher & Piyush Joshi & Maxwell P. Gold & Julia Sundheimer & Britta Statz & Ahmet S. Rifaiog, 2024. "Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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