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Pericytes are required for blood–brain barrier integrity during embryogenesis

Author

Listed:
  • Richard Daneman

    (513 Parnassus Avenue, HSW1301, San Francisco, California 94143-0452, USA)

  • Lu Zhou

    (Stanford University School of Medicine, Fairchild Science Building D200, Stanford, California 94305-5125, USA)

  • Amanuel A. Kebede

    (513 Parnassus Avenue, HSW1301, San Francisco, California 94143-0452, USA)

  • Ben A. Barres

    (Stanford University School of Medicine, Fairchild Science Building D200, Stanford, California 94305-5125, USA)

Abstract

Building the blood–brain barrier The blood–brain barrier is a gatekeeper between the central nervous system and the rest of the body, and is made up of vascular endothelial cells. Previous work upheld the notion that the barrier was formed postnatally as a result of signalling from non-neuronal cells called astrocytes to endothelial cells. Now, two independent studies demonstrate that the barrier is in fact formed during embryogenesis, with the critical factor being the interaction between blood-vessel-surrounding cells called pericytes and epithelial cells. A better understanding of the tight relationship between pericytes, neuroendothelial cells and astrocytes in blood–brain barrier function will contribute to our understanding of the breakdown of the barrier during central nervous system injury and disease.

Suggested Citation

  • Richard Daneman & Lu Zhou & Amanuel A. Kebede & Ben A. Barres, 2010. "Pericytes are required for blood–brain barrier integrity during embryogenesis," Nature, Nature, vol. 468(7323), pages 562-566, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7323:d:10.1038_nature09513
    DOI: 10.1038/nature09513
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    Cited by:

    1. Andrée-Anne Berthiaume & Franca Schmid & Stefan Stamenkovic & Vanessa Coelho-Santos & Cara D. Nielson & Bruno Weber & Mark W. Majesky & Andy Y. Shih, 2022. "Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Kevin Boyé & Luiz Henrique Geraldo & Jessica Furtado & Laurence Pibouin-Fragner & Mathilde Poulet & Doyeun Kim & Bryce Nelson & Yunling Xu & Laurent Jacob & Nawal Maissa & Dritan Agalliu & Lena Claess, 2022. "Endothelial Unc5B controls blood-brain barrier integrity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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