IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7322d10.1038_nature09430.html
   My bibliography  Save this article

Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor

Author

Listed:
  • Laura B. Sheard

    (Box 357280, University of Washington)

  • Xu Tan

    (Box 357280, University of Washington
    Present address: Division of Genetics, Brigham and Women’s Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.)

  • Haibin Mao

    (Box 357280, University of Washington)

  • John Withers

    (Michigan State University
    Michigan State University)

  • Gili Ben-Nissan

    (Weizmann Institute of Science)

  • Thomas R. Hinds

    (Box 357280, University of Washington)

  • Yuichi Kobayashi

    (Tokyo Institute of Technology, 4259-B52 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan)

  • Fong-Fu Hsu

    (Mass Spectrometry Resource, Diabetes, Metabolism, and Lipid research, Washington University School of Medicine)

  • Michal Sharon

    (Weizmann Institute of Science)

  • John Browse

    (Institute of Biological Chemistry, Washington State University)

  • Sheng Yang He

    (Michigan State University
    Michigan State University)

  • Josep Rizo

    (University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA)

  • Gregg A. Howe

    (Michigan State University
    Michigan State University)

  • Ning Zheng

    (Box 357280, University of Washington
    Howard Hughes Medical Institute, University of Washington)

Abstract

Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JAZ proteins. Despite its importance, the mechanism of jasmonate perception remains unclear. Here we present structural and pharmacological data to show that the true Arabidopsis jasmonate receptor is a complex of both COI1 and JAZ. COI1 contains an open pocket that recognizes the bioactive hormone (3R,7S)-jasmonoyl-l-isoleucine (JA-Ile) with high specificity. High-affinity hormone binding requires a bipartite JAZ degron sequence consisting of a conserved α-helix for COI1 docking and a loop region to trap the hormone in its binding pocket. In addition, we identify a third critical component of the jasmonate co-receptor complex, inositol pentakisphosphate, which interacts with both COI1 and JAZ adjacent to the ligand. Our results unravel the mechanism of jasmonate perception and highlight the ability of F-box proteins to evolve as multi-component signalling hubs.

Suggested Citation

  • Laura B. Sheard & Xu Tan & Haibin Mao & John Withers & Gili Ben-Nissan & Thomas R. Hinds & Yuichi Kobayashi & Fong-Fu Hsu & Michal Sharon & John Browse & Sheng Yang He & Josep Rizo & Gregg A. Howe & N, 2010. "Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor," Nature, Nature, vol. 468(7322), pages 400-405, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09430
    DOI: 10.1038/nature09430
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09430
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09430?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lingmin Yuan & Fei Gao & Zongyang Lv & Digant Nayak & Anindita Nayak & Priscila dos Santos Bury & Kristin E. Cano & Lijia Jia & Natalia Oleinik & Firdevs Cansu Atilgan & Besim Ogretmen & Katelyn M. Wi, 2022. "Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Zi-Wei Yan & Fang-Yan Chen & Xian Zhang & Wen-Juan Cai & Chun-Yu Chen & Jie Liu & Man-Ni Wu & Ning-Jing Liu & Bin Ma & Mu-Yang Wang & Dai-Yin Chao & Cai-Ji Gao & Ying-Bo Mao, 2023. "Endocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Shiyun Cao & Shoukai Kang & Haibin Mao & Jiayu Yao & Liangcai Gu & Ning Zheng, 2022. "Defining molecular glues with a dual-nanobody cannabidiol sensor," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09430. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.