IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7321d10.1038_nature09493.html
   My bibliography  Save this article

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

Author

Listed:
  • Bi-Sen Ding

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • Daniel J. Nolan

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • Jason M. Butler

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • Daylon James

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • Alexander O. Babazadeh

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • Zev Rosenwaks

    (Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine)

  • Vivek Mittal

    (Weill Cornell Medical College)

  • Hideki Kobayashi

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • Koji Shido

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

  • David Lyden

    (Weill Cornell Medical College)

  • Thomas N. Sato

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan)

  • Sina Y. Rabbany

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College
    Bioengineering Program, Hofstra University, Hempstead, New York 11549, USA)

  • Shahin Rafii

    (Howard Hughes Medical Institute, Ansary Stem Cell Institute, Weill Cornell Medical College)

Abstract

Liver regeneration signals There is growing evidence to suggest that endothelial cells are not simply passive conduits for delivering oxygen and nutrients. During embryogenesis, for instance, they induce organogenesis before the circulation has developed. Experiments in a 70% partial hepatectomy liver regeneration model in mice now reveal a molecular pathway by which endothelial cells can sustain liver regeneration after surgical resection. VEGFR2 activation in a defined subpopulation of liver endothelial cells leads to the upregulation of the endothelial-specific transcription factor Id1, which in turn induces the secretion of Wnt2 and hepatocyte growth factor (HGF), which trigger hepatocyte proliferation. This suggests that vascular niche-derived inductive signals that promote liver regeneration could be utilized to initiate and accelerate liver recovery after these surgical procedures.

Suggested Citation

  • Bi-Sen Ding & Daniel J. Nolan & Jason M. Butler & Daylon James & Alexander O. Babazadeh & Zev Rosenwaks & Vivek Mittal & Hideki Kobayashi & Koji Shido & David Lyden & Thomas N. Sato & Sina Y. Rabbany , 2010. "Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration," Nature, Nature, vol. 468(7321), pages 310-315, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09493
    DOI: 10.1038/nature09493
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09493
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09493?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Germán Belenguer & Gianmarco Mastrogiovanni & Clare Pacini & Zoe Hall & Anna M. Dowbaj & Robert Arnes-Benito & Aleksandra Sljukic & Nicole Prior & Sofia Kakava & Charles R. Bradshaw & Susan Davies & M, 2022. "RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Linda Große-Segerath & Paula Follert & Kristina Behnke & Julia Ettich & Tobias Buschmann & Philip Kirschner & Sonja Hartwig & Stefan Lehr & Mortimer Korf-Klingebiel & Daniel Eberhard & Nadja Lehwald-T, 2024. "Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Hirotoki Ohkubo & Yoshiya Ito & Tsutomu Minamino & Koji Eshima & Ken Kojo & Shin-ichiro Okizaki & Mitsuhiro Hirata & Masabumi Shibuya & Masahiko Watanabe & Masataka Majima, 2014. "VEGFR1-Positive Macrophages Facilitate Liver Repair and Sinusoidal Reconstruction after Hepatic Ischemia/Reperfusion Injury," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-14, August.
    4. Cyrill Géraud & Konstantin Evdokimov & Beate K Straub & Wiebke K Peitsch & Alexandra Demory & Yvette Dörflinger & Kai Schledzewski & Astrid Schmieder & Peter Schemmer & Hellmut G Augustin & Peter Schi, 2012. "Unique Cell Type-Specific Junctional Complexes in Vascular Endothelium of Human and Rat Liver Sinusoids," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-12, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09493. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.