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Asterless is a scaffold for the onset of centriole assembly

Author

Listed:
  • Nikola S. Dzhindzhev

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge)

  • Quan D. Yu

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge)

  • Kipp Weiskopf

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
    Present Address: Stanford University School of Medicine, Stanford, California 94305, USA.)

  • George Tzolovsky

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge)

  • Ines Cunha-Ferreira

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
    Instituto Gulbenkian de Ciencia)

  • Maria Riparbelli

    (Università di Siena, via Aldo Moro, 2-53100 Siena, Italy)

  • Ana Rodrigues-Martins

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
    Instituto Gulbenkian de Ciencia)

  • Monica Bettencourt-Dias

    (Instituto Gulbenkian de Ciencia)

  • Giuliano Callaini

    (Università di Siena, via Aldo Moro, 2-53100 Siena, Italy)

  • David M. Glover

    (Cancer Research UK Cell Cycle Genetics Group, University of Cambridge)

Abstract

On the scaffold Centrioles, cellular organelles composed of cylindrical arrays of nine microtubules, are essential for the formation of cilia, flagella and the centrosomes that organize microtubule structures within animal cells. Abnormal regulation of centriole duplication can lead to cancers and a number of ciliary diseases, and the centriolar protein Plk4 (Polo-like-kinase 4) is known to be a key regulator of centriole assembly. Now, David Glover and colleagues identify a single centriolar component, Asterless, as a scaffold for the binding of both Plk4 and another protein essential for centriole formation, Sas-4, with a key role in promoting centriole duplication.

Suggested Citation

  • Nikola S. Dzhindzhev & Quan D. Yu & Kipp Weiskopf & George Tzolovsky & Ines Cunha-Ferreira & Maria Riparbelli & Ana Rodrigues-Martins & Monica Bettencourt-Dias & Giuliano Callaini & David M. Glover, 2010. "Asterless is a scaffold for the onset of centriole assembly," Nature, Nature, vol. 467(7316), pages 714-718, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7316:d:10.1038_nature09445
    DOI: 10.1038/nature09445
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    Cited by:

    1. Pallavi Panda & Mark S. Ladinsky & David M. Glover, 2024. "9-fold symmetry is not essential for centriole elongation and formation of new centriole-like structures," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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