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The ploidy conveyor of mature hepatocytes as a source of genetic variation

Author

Listed:
  • Andrew W. Duncan

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University)

  • Matthew H. Taylor

    (Oregon Health & Science University)

  • Raymond D. Hickey

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University
    Oregon Health & Science University)

  • Amy E. Hanlon Newell

    (Oregon Health & Science University)

  • Michelle L. Lenzi

    (Oregon Health & Science University)

  • Susan B. Olson

    (Oregon Health & Science University)

  • Milton J. Finegold

    (Texas Children’s Hospital, Houston, Texas 77030, USA)

  • Markus Grompe

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University)

Abstract

Polyploidy in liver cells Many liver cells are polyploid, containing 4, 8, 16 or more times the haploid chromosome complement, although the significance of the phenomenon is not known. A study in mice now shows that hepatocytes can both increase and decrease their ploidy in vivo. Ploidy reversal was previously thought to be exclusive to meiosis, but this work shows that it can also occur in normal somatic cells. Increases in ploidy occur through failed cytokinesis, and decreases as a result of multipolar mitosis. The resulting genetic heterogeneity might be advantageous following hepatic injury when 'genetically robust' cells could be selected from a pre-existing pool of diverse genotypes.

Suggested Citation

  • Andrew W. Duncan & Matthew H. Taylor & Raymond D. Hickey & Amy E. Hanlon Newell & Michelle L. Lenzi & Susan B. Olson & Milton J. Finegold & Markus Grompe, 2010. "The ploidy conveyor of mature hepatocytes as a source of genetic variation," Nature, Nature, vol. 467(7316), pages 707-710, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7316:d:10.1038_nature09414
    DOI: 10.1038/nature09414
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    Cited by:

    1. Ross J. Hill & Nazareno Bona & Job Smink & Hannah K. Webb & Alastair Crisp & Juan I. Garaycoechea & Gerry P. Crossan, 2024. "p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ren Guo & Mengmeng Jiang & Gang Wang & Bing Li & Xiaohui Jia & Yan Ai & Shanshan Chen & Peilan Tang & Aijie Liu & Qianting Yuan & Xin Xie, 2022. "IL6 supports long-term expansion of hepatocytes in vitro," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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