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Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows

Author

Listed:
  • Mirjam Mayer

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Max Planck Institute for the Physics of Complex Systems)

  • Martin Depken

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Max Planck Institute for the Physics of Complex Systems
    Present address: Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.)

  • Justin S. Bois

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Max Planck Institute for the Physics of Complex Systems)

  • Frank Jülicher

    (Max Planck Institute for the Physics of Complex Systems)

  • Stephan W. Grill

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Max Planck Institute for the Physics of Complex Systems)

Abstract

Go with the actomyosin flow Cortical flows of actomyosin are central to many processes in cellular and developmental biology. In the one-cell Caenorhabditis elegans embryo, anteroposterior polarity, a prerequisite for asymmetric cell division, is established by large-scale flow of the actomyosin cortex that segregates cortical polarity proteins between the anterior and posterior domains. The underlying forces and physical principles behind long-range flow remain unclear. Mayer et al. have devised a novel method to measure cortical tension (total mechanical tension) and find that cortical flows are driven by contractility of the actomyosin network. The direction of flow depends on anisotropies in the cortical tension, and long-range cortical flow occurs only if the cortex is sufficiently viscous.

Suggested Citation

  • Mirjam Mayer & Martin Depken & Justin S. Bois & Frank Jülicher & Stephan W. Grill, 2010. "Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows," Nature, Nature, vol. 467(7315), pages 617-621, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7315:d:10.1038_nature09376
    DOI: 10.1038/nature09376
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    Cited by:

    1. Christina Rou Hsu & Gaganpreet Sangha & Wayne Fan & Joey Zheng & Kenji Sugioka, 2023. "Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Sorosh Amiri & Camelia Muresan & Xingbo Shang & Clotilde Huet-Calderwood & Martin A. Schwartz & David A. Calderwood & Michael Murrell, 2023. "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Binh An Truong Quang & Ruby Peters & Davide A. D. Cassani & Priyamvada Chugh & Andrew G. Clark & Meghan Agnew & Guillaume Charras & Ewa K. Paluch, 2021. "Extent of myosin penetration within the actin cortex regulates cell surface mechanics," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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