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Genome-wide analysis of a long-term evolution experiment with Drosophila

Author

Listed:
  • Molly K. Burke

    (Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA)

  • Joseph P. Dunham

    (Molecular and Computational Biology, University of Southern California)

  • Parvin Shahrestani

    (Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA)

  • Kevin R. Thornton

    (Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA)

  • Michael R. Rose

    (Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA)

  • Anthony D. Long

    (Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA)

Abstract

Experimental evolution reveals resistance to change Until now, experimental evolution has been largely performed in asexual systems with small genomes, such as bacteria and yeast. Burke et al. report results of a genome-wide study in Drosophila melanogaster fruitfly populations, which were selected in the lab for more than 600 generations to develop rapidly from egg to adult. In contrast to what is seen in asexual populations, the authors report 'soft' selective sweeps in which selection acts on pre-existing, common genetic variants, and conclude that unconditionally advantageous alleles rarely arise, are associated with small net fitness gains, or cannot fix because selection coefficients change over time.

Suggested Citation

  • Molly K. Burke & Joseph P. Dunham & Parvin Shahrestani & Kevin R. Thornton & Michael R. Rose & Anthony D. Long, 2010. "Genome-wide analysis of a long-term evolution experiment with Drosophila," Nature, Nature, vol. 467(7315), pages 587-590, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7315:d:10.1038_nature09352
    DOI: 10.1038/nature09352
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    Cited by:

    1. David B. Stern & Nathan W. Anderson & Juanita A. Diaz & Carol Eunmi Lee, 2022. "Genome-wide signatures of synergistic epistasis during parallel adaptation in a Baltic Sea copepod," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Joseph L. Graves Jr., 2015. "Great Is Their Sin," The ANNALS of the American Academy of Political and Social Science, , vol. 661(1), pages 24-50, September.
    3. Mellissa Marcus & Terence C. Burnham & David W. Stephens & Aimee S. Dunlap, 2018. "Experimental evolution of color preference for oviposition in Drosophila melanogaster," Journal of Bioeconomics, Springer, vol. 20(1), pages 125-140, April.

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