IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v467y2010i7315d10.1038_nature09339.html
   My bibliography  Save this article

Translating cancer research into targeted therapeutics

Author

Listed:
  • J. S. de Bono

    (The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK)

  • Alan Ashworth

    (The Breakthrough Breast Cancer Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK)

Abstract

The route to targeted anticancer drugs In a Perspectives review, Johann de Bono and Alan Ashworth take a critical look at current procedures for clinical trials in cancer. The emphasis of anticancer drug development is now firmly on molecularly targeted, rationally designed agents rather than nonspecific cytotoxins. Yet despite some successes, the prognosis for many cancers — such as pancreatic and lung cancer — remains poor. Many trials have little effect on either patient outcome or our understanding of cancer biology, arriving instead at a best treatment for the average patient rather than for any individual. De Bono and Ashworth argue for a new approach involving integrated cancer research and biomarker-driven adaptive and hypothesis testing clinical trials. The potential of structure-guided drug discovery in treating cancer is demonstrated elsewhere in this issue in a paper on the B-RAF inhibitor PLX4032; see, http://go.nature.com/QnVGQx ).

Suggested Citation

  • J. S. de Bono & Alan Ashworth, 2010. "Translating cancer research into targeted therapeutics," Nature, Nature, vol. 467(7315), pages 543-549, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7315:d:10.1038_nature09339
    DOI: 10.1038/nature09339
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09339
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09339?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sjoerd T Ligthart & Frank A W Coumans & Gerhardt Attard & Amy Mulick Cassidy & Johann S de Bono & Leon W M M Terstappen, 2011. "Unbiased and Automated Identification of a Circulating Tumour Cell Definition That Associates with Overall Survival," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-8, November.
    2. Sidrah Shah & Alison Cheung & Mikolaj Kutka & Matin Sheriff & Stergios Boussios, 2022. "Epithelial Ovarian Cancer: Providing Evidence of Predisposition Genes," IJERPH, MDPI, vol. 19(13), pages 1-14, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:467:y:2010:i:7315:d:10.1038_nature09339. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.