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Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking

Author

Listed:
  • Alan R. Lowe

    (University of California
    QB3, University of California
    Bay Area Physical Sciences–Oncology Center, University of California
    Lawrence Berkeley National Laboratory, California 94720, USA)

  • Jake J. Siegel

    (QB3, University of California
    Biophysics Graduate Group, University of California)

  • Petr Kalab

    (University of California
    Present addresses: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA (P.K.); Illumina Inc., Hayward, California 94545, USA (M.S.).)

  • Merek Siu

    (Biophysics Graduate Group, University of California
    Present addresses: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA (P.K.); Illumina Inc., Hayward, California 94545, USA (M.S.).)

  • Karsten Weis

    (QB3, University of California
    University of California)

  • Jan T. Liphardt

    (University of California
    QB3, University of California
    Bay Area Physical Sciences–Oncology Center, University of California
    Biophysics Graduate Group, University of California)

Abstract

Nuclear pore complex selectivity Nuclear pore complexes selectively transport cargoes across the nuclear envelope. Now, two studies published in this issue follow the movement of single cargo proteins (Lowe et al.) and mRNA transcripts (David Grünwald and Robert Singer) as they translocate across the nuclear envelope, with nanometre precision and high temporal resolution. They discover previously unidentified transport sub-steps and provide fundamental insight into the mechanism of selective transport through the nuclear pore complexes.

Suggested Citation

  • Alan R. Lowe & Jake J. Siegel & Petr Kalab & Merek Siu & Karsten Weis & Jan T. Liphardt, 2010. "Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking," Nature, Nature, vol. 467(7315), pages 600-603, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7315:d:10.1038_nature09285
    DOI: 10.1038/nature09285
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    Cited by:

    1. Jan Andreas Ruland & Annika Marie Krüger & Kerstin Dörner & Rohan Bhatia & Sabine Wirths & Daniel Poetes & Ulrike Kutay & Jan Peter Siebrasse & Ulrich Kubitscheck, 2021. "Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Ruhollah Moussavi-Baygi & Yousef Jamali & Reza Karimi & Mohammad R K Mofrad, 2011. "Brownian Dynamics Simulation of Nucleocytoplasmic Transport: A Coarse-Grained Model for the Functional State of the Nuclear Pore Complex," PLOS Computational Biology, Public Library of Science, vol. 7(6), pages 1-16, June.
    3. David Winogradoff & Han-Yi Chou & Christopher Maffeo & Aleksei Aksimentiev, 2022. "Percolation transition prescribes protein size-specific barrier to passive transport through the nuclear pore complex," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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