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Comprehensive methylome map of lineage commitment from haematopoietic progenitors

Author

Listed:
  • Hong Ji

    (Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA)

  • Lauren I. R. Ehrlich

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Present addresses: Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas 78712, USA (L.I.R.E.); Immune Disease Institute, Harvard Stem Cell Institute Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA (D.J.R.); Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA (T.S.); Cellant Therapeutics, San Carlos, California 94070, USA (H.K.).)

  • Jun Seita

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Peter Murakami

    (Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA)

  • Akiko Doi

    (Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA)

  • Paul Lindau

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Hwajin Lee

    (Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA)

  • Martin J. Aryee

    (Johns Hopkins Bloomberg School of Public Health
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University)

  • Rafael A. Irizarry

    (Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
    Johns Hopkins Bloomberg School of Public Health)

  • Kitai Kim

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Harvard Medical School; Harvard Stem Cell Institute
    Brigham and Women’s Hospital)

  • Derrick J. Rossi

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Present addresses: Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas 78712, USA (L.I.R.E.); Immune Disease Institute, Harvard Stem Cell Institute Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA (D.J.R.); Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA (T.S.); Cellant Therapeutics, San Carlos, California 94070, USA (H.K.).)

  • Matthew A. Inlay

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Thomas Serwold

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Present addresses: Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas 78712, USA (L.I.R.E.); Immune Disease Institute, Harvard Stem Cell Institute Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA (D.J.R.); Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA (T.S.); Cellant Therapeutics, San Carlos, California 94070, USA (H.K.).)

  • Holger Karsunky

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Present addresses: Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas 78712, USA (L.I.R.E.); Immune Disease Institute, Harvard Stem Cell Institute Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA (D.J.R.); Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA (T.S.); Cellant Therapeutics, San Carlos, California 94070, USA (H.K.).)

  • Lena Ho

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • George Q. Daley

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Harvard Medical School; Harvard Stem Cell Institute
    Brigham and Women’s Hospital)

  • Irving L. Weissman

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Andrew P. Feinberg

    (Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA)

Abstract

Stem cells with baggage Induced pluripotent stem (iPS) cells are produced by reprogramming differentiated adult cells using a cocktail of transcription factors. They share many properties that are characteristic of embryonic stem (ES) cells generated by somatic-cell nuclear transfer (SCNT), and of ES cells from naturally fertilized embryos. The three cell types are not identical, however, and an interesting difference has now been discovered: iPS cells retain an 'epigenetic memory' of the donor tissue from which they derive, whereas SCNT-based reprogramming resets the DNA-methylation state of adult cells so it is closer to the ES cell-like state. In a separate study, Ji et al. examine the role of specific DNA methylation marks in the developmental progression of particular cell lineages. They present a genome-wide DNA-methylation analysis of haematopoietic cell populations that reveals remarkable epigenetic plasticity. Changes in DNA methylation emerge as perhaps a principal factor directing cell-fate choices such as commitment to myeloid or lymphoid development.

Suggested Citation

  • Hong Ji & Lauren I. R. Ehrlich & Jun Seita & Peter Murakami & Akiko Doi & Paul Lindau & Hwajin Lee & Martin J. Aryee & Rafael A. Irizarry & Kitai Kim & Derrick J. Rossi & Matthew A. Inlay & Thomas Ser, 2010. "Comprehensive methylome map of lineage commitment from haematopoietic progenitors," Nature, Nature, vol. 467(7313), pages 338-342, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7313:d:10.1038_nature09367
    DOI: 10.1038/nature09367
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    Cited by:

    1. Jun Seita & Debashis Sahoo & Derrick J Rossi & Deepta Bhattacharya & Thomas Serwold & Matthew A Inlay & Lauren I R Ehrlich & John W Fathman & David L Dill & Irving L Weissman, 2012. "Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-11, July.
    2. Roger Mulet-Lazaro & Stanley Herk & Margit Nuetzel & Aniko Sijs-Szabo & Noelia Díaz & Katherine Kelly & Claudia Erpelinck-Verschueren & Lucia Schwarzfischer-Pfeilschifter & Hanna Stanewsky & Ute Acker, 2024. "Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Ihab Ansari & Llorenç Solé-Boldo & Meshi Ridnik & Julian Gutekunst & Oliver Gilliam & Maria Korshko & Timur Liwinski & Birgit Jickeli & Noa Weinberg-Corem & Michal Shoshkes-Carmel & Eli Pikarsky & Era, 2023. "TET2 and TET3 loss disrupts small intestine differentiation and homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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