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Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

Author

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  • Adan Aguirre

    (Center for Neuroscience Research, Children’s National Medical Center
    Present address: SUNY at Stony Brook University, Pharmacology Department, Stony Brook, New York 11794-5140, USA.)

  • Maria E. Rubio

    (University of Pittsburgh Medical School)

  • Vittorio Gallo

    (Center for Neuroscience Research, Children’s National Medical Center)

Abstract

Neural stem cells in balance The subventricular zone (SVZ) of the adult mammalian brain is an important site for cell proliferation, contributing to nerve-cell self-renewal and the response to injury. The SVZ stem-cell niche maintains neural stem cells (NSCs) and neural progenitor cells (NPCs), with the balance between the two being vital to normal brain development. Notch signalling is known to regulate NSC self-renewal, whereas EGFR (epidermal growth factor receptor) signalling affects NPC proliferation. Aguirre et al. show that these pathways interact to maintain a balance between NSC and NPC populations through EGFR-mediated regulation of Notch signalling. This points to specific signalling pathways that may be targeted to enhance production of NSCs or NPCs after injury.

Suggested Citation

  • Adan Aguirre & Maria E. Rubio & Vittorio Gallo, 2010. "Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal," Nature, Nature, vol. 467(7313), pages 323-327, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7313:d:10.1038_nature09347
    DOI: 10.1038/nature09347
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    Cited by:

    1. Qiwen Sun & Zhaohang Cai & Chunjuan Zhu, 2022. "A Novel Dynamical Regulation of mRNA Distribution by Cross-Talking Pathways," Mathematics, MDPI, vol. 10(9), pages 1-14, May.
    2. Balazs V. Varga & Maryam Faiz & Helena Pivonkova & Gabriel Khelifi & Huijuan Yang & Shangbang Gao & Emma Linderoth & Mei Zhen & Ragnhildur Thora Karadottir & Samer M. Hussein & Andras Nagy, 2022. "Signal requirement for cortical potential of transplantable human neuroepithelial stem cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Zhang, Yuan & Cao, Jinde & Liu, Lixia & Liu, Haihong & Li, Zhouhong, 2024. "Complex role of time delay in dynamical coordination of neural progenitor fate decisions mediated by Notch pathway," Chaos, Solitons & Fractals, Elsevier, vol. 180(C).

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