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Graphene as a subnanometre trans-electrode membrane

Author

Listed:
  • S. Garaj

    (Harvard University)

  • W. Hubbard

    (School of Engineering and Applied Sciences, Harvard University)

  • A. Reina

    (Massachusetts Institute of Technology)

  • J. Kong

    (Massachusetts Institute of Technology)

  • D. Branton

    (Harvard University)

  • J. A. Golovchenko

    (Harvard University
    School of Engineering and Applied Sciences, Harvard University)

Abstract

DNA sequencing: enter the graphene nanopore Atomically thin layers of graphite — known as graphene — are highly electronically conducting across the plane of the material. Now researchers from Harvard University and the Massachusetts Institute of Technology show that, when used as a membrane separating two liquid reservoirs, graphene is strongly ionically insulating, while its in-plane electronic properties are strongly dependent on the inter-facial environment. The membrane prevents ions and water from flowing through it, but can attract various ions and other molecules to its two atomically close surfaces. A variety of analytical applications may result. For instance, the authors show that by drilling pores a few nanometres in diameter into these 'trans-electrode' membranes, it is possible to thread a long DNA molecule through the graphene nanopore. The DNA blocks the flow of ions, resulting in a characteristic electrical signal reflecting the size and conformation of the molecule. Such a system has potential as the basis of devices that could significantly reduce the cost of DNA sequencing.

Suggested Citation

  • S. Garaj & W. Hubbard & A. Reina & J. Kong & D. Branton & J. A. Golovchenko, 2010. "Graphene as a subnanometre trans-electrode membrane," Nature, Nature, vol. 467(7312), pages 190-193, September.
  • Handle: RePEc:nat:nature:v:467:y:2010:i:7312:d:10.1038_nature09379
    DOI: 10.1038/nature09379
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    Cited by:

    1. Shihao Su & Yifan Zhang & Shengyuan Peng & Linxin Guo & Yong Liu & Engang Fu & Huijun Yao & Jinlong Du & Guanghua Du & Jianming Xue, 2022. "Multifunctional graphene heterogeneous nanochannel with voltage-tunable ion selectivity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Zhen Zhang & Preeti Bhauriyal & Hafeesudeen Sahabudeen & Zhiyong Wang & Xiaohui Liu & Mike Hambsch & Stefan C. B. Mannsfeld & Renhao Dong & Thomas Heine & Xinliang Feng, 2022. "Cation-selective two-dimensional polyimine membranes for high-performance osmotic energy conversion," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Shams ur Rahman & Waqqar Ahmed & Najeeb Ur Rehman & Mohammad Alkhedher & ElSayed M. Tag El Din, 2022. "Fabrication of Graphene Sheets Using an Atmospheric Pressure Thermal Plasma Jet System," Energies, MDPI, vol. 15(19), pages 1-9, October.
    4. Taheri Najafabadi, Amin, 2015. "Emerging applications of graphene and its derivatives in carbon capture and conversion: Current status and future prospects," Renewable and Sustainable Energy Reviews, Elsevier, vol. 41(C), pages 1515-1545.

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