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A spindle-independent cleavage furrow positioning pathway

Author

Listed:
  • Clemens Cabernard

    (Howard Hughes Medical Institute, University of Oregon
    Institute of Molecular Biology, University of Oregon
    Institute of Neuroscience, University of Oregon)

  • Kenneth E. Prehoda

    (Institute of Molecular Biology, University of Oregon)

  • Chris Q. Doe

    (Howard Hughes Medical Institute, University of Oregon
    Institute of Molecular Biology, University of Oregon
    Institute of Neuroscience, University of Oregon)

Abstract

Where cells divide In the textbook model of metazoan cell division — based on a century of work on relatively large marine cells and Caenorhabditis elegans — the mitotic spindle is assumed to direct the position of the cleavage furrow. Now experiments to test whether this model is sufficient to explain furrow position during asymmetric cell division of a smaller cell — the Drosophila neuroblast — suggest that it cannot. Instead, a novel pathway operates in which the Pins (Partner of Inscuteable) polarity complex polarizes furrow-forming proteins to the basal cortex where they induce contractile ring formation. This spindle-independent cytokinetic furrow mechanism may be relevant to other highly polarized cell types.

Suggested Citation

  • Clemens Cabernard & Kenneth E. Prehoda & Chris Q. Doe, 2010. "A spindle-independent cleavage furrow positioning pathway," Nature, Nature, vol. 467(7311), pages 91-94, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7311:d:10.1038_nature09334
    DOI: 10.1038/nature09334
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    Cited by:

    1. Emilie Montembault & Irène Deduyer & Marie-Charlotte Claverie & Lou Bouit & Nicolas J. Tourasse & Denis Dupuy & Derek McCusker & Anne Royou, 2023. "Two RhoGEF isoforms with distinct localisation control furrow position during asymmetric cell division," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Ryota Sakamoto & Michael P. Murrell, 2024. "Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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