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Structure of the torque ring of the flagellar motor and the molecular basis for rotational switching

Author

Listed:
  • Lawrence K. Lee

    (The Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia)

  • Michael A. Ginsburg

    (The Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia)

  • Claudia Crovace

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK)

  • Mhairi Donohoe

    (The Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia)

  • Daniela Stock

    (The Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia
    Faculty of Medicine, University of New South Wales)

Abstract

Ringing the direction changes Rotation of the bacterial flagellar filament is responsible for bacterial motility. The direction of rotation determines whether the bacteria run smoothly forward or tumble to change their trajectory. The flagellar motor drives this rotation either clockwise or counter-clockwise, with the direction regulated by the flagellar switch complex. One of its components, a ring-shaped protein called FliG, applies the twisting motion or torque that enables the motor to switch direction — a notable feat since the flagellum rotates at hundreds of revolutions per second, yet reverses direction in less than a millisecond. The full-length structure of FliG has now been determined, and the conformational changes that are involved in switching between the direction of rotation identified.

Suggested Citation

  • Lawrence K. Lee & Michael A. Ginsburg & Claudia Crovace & Mhairi Donohoe & Daniela Stock, 2010. "Structure of the torque ring of the flagellar motor and the molecular basis for rotational switching," Nature, Nature, vol. 466(7309), pages 996-1000, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7309:d:10.1038_nature09300
    DOI: 10.1038/nature09300
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    Cited by:

    1. William R Taylor & Teige R S Matthews-Palmer & Morgan Beeby, 2016. "Molecular Models for the Core Components of the Flagellar Type-III Secretion Complex," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-33, November.

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