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Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases

Author

Listed:
  • Yannick Jacob

    (Indiana University)

  • Hume Stroud

    (Cell and Developmental Biology, University of California, Los Angeles)

  • Chantal LeBlanc

    (Indiana University)

  • Suhua Feng

    (Howard Hughes Medical Institute, University of California, Los Angeles)

  • Luting Zhuo

    (Indiana University)

  • Elena Caro

    (Cell and Developmental Biology, University of California, Los Angeles)

  • Christiane Hassel

    (Indiana University)

  • Crisanto Gutierrez

    (Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Nicolas Cabrera 1, Cantoblanco, Madrid 28049, Spain)

  • Scott D. Michaels

    (Indiana University)

  • Steven E. Jacobsen

    (Cell and Developmental Biology, University of California, Los Angeles
    Howard Hughes Medical Institute, University of California, Los Angeles)

Abstract

DNA replication: applying the brakes It is important for the normal function of a cell that DNA replication takes place only once per cell cycle, and various mechanisms exist to prevent its repetition. Another mechanism has been shown to operate in Arabidopsis, this one surprisingly involving two histone (H3K27) monomethyltansferases, ATXR5 and ATXR6. Mutations in the genes encoding these two enzymes lead to re-replication of specific genomic locations, the majority of which correspond to transposons and other repetitive and silenced elements. ATXR5 and ATXR6 are proposed to be components of a pathway required to prevent over-replication of heterochromatin in Arabidopsis.

Suggested Citation

  • Yannick Jacob & Hume Stroud & Chantal LeBlanc & Suhua Feng & Luting Zhuo & Elena Caro & Christiane Hassel & Crisanto Gutierrez & Scott D. Michaels & Steven E. Jacobsen, 2010. "Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases," Nature, Nature, vol. 466(7309), pages 987-991, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7309:d:10.1038_nature09290
    DOI: 10.1038/nature09290
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    Cited by:

    1. Zaida Vergara & María S. Gomez & Bénédicte Desvoyes & Joana Sequeira-Mendes & Kinda Masoud & Celina Costas & Sandra Noir & Elena Caro & Victoria Mora-Gil & Pascal Genschik & Crisanto Gutierrez, 2023. "Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Zhen Wang & Claudia M. Castillo-González & Changjiang Zhao & Chun-Yip Tong & Changhao Li & Songxiao Zhong & Zhiyang Liu & Kaili Xie & Jiaying Zhu & Zhongshou Wu & Xu Peng & Yannick Jacob & Scott D. Mi, 2023. "H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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