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Phenotypic robustness conferred by apparently redundant transcriptional enhancers

Author

Listed:
  • Nicolás Frankel

    (Princeton University, Princeton, New Jersey 08544, USA)

  • Gregory K. Davis

    (Bryn Mawr College, 101 N. Merion Ave, Bryn Mawr, Pennsylvania 19010, USA)

  • Diego Vargas

    (Princeton University, Princeton, New Jersey 08544, USA)

  • Shu Wang

    (Princeton University, Princeton, New Jersey 08544, USA)

  • François Payre

    (Université de Toulouse and Centre National de la Recherche Scientifique, Centre de Biologie du Développement, UMR5547, Toulouse, F-31062, France)

  • David L. Stern

    (Princeton University, Princeton, New Jersey 08544, USA)

Abstract

Back-up enhancers protect phenotype Transcriptional enhancers are segments of regulatory DNA located some distance from the coding region of a gene. Sometimes, several of them can serve apparently redundant functions — driving the production of a gene's messenger RNA at the same stage and place in embryonic development. Frankel et al. now demonstrate in Drosophila that such 'redundant' enhancers (in this case, two enhancers of the embryo-patterning gene shavenbaby), by contributing higher overall levels of transcription, ensure robustness of phenotypes against both genetic and environmental perturbations; for example, mutations in other genes or temperature changes that would otherwise lead to aberrant development.

Suggested Citation

  • Nicolás Frankel & Gregory K. Davis & Diego Vargas & Shu Wang & François Payre & David L. Stern, 2010. "Phenotypic robustness conferred by apparently redundant transcriptional enhancers," Nature, Nature, vol. 466(7305), pages 490-493, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7305:d:10.1038_nature09158
    DOI: 10.1038/nature09158
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    Cited by:

    1. Brent S. Perlman & Noah Burget & Yeqiao Zhou & Gregory W. Schwartz & Jelena Petrovic & Zora Modrusan & Robert B. Faryabi, 2024. "Enhancer-promoter hubs organize transcriptional networks promoting oncogenesis and drug resistance," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Samuel Abassah-Oppong & Matteo Zoia & Brandon J. Mannion & Raquel Rouco & Virginie Tissières & Cailyn H. Spurrell & Virginia Roland & Fabrice Darbellay & Anja Itum & Julie Gamart & Tabitha A. Festa-Da, 2024. "A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    3. Mukta Kundu & Alexander Kuzin & Tzu-Yang Lin & Chi-Hon Lee & Thomas Brody & Ward F Odenwald, 2013. "cis-Regulatory Complexity within a Large Non-Coding Region in the Drosophila Genome," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-14, April.
    4. Matthew J Harder & Julie Hix & Wendy M Reeves & Michael T Veeman, 2021. "Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships," PLOS Genetics, Public Library of Science, vol. 17(1), pages 1-23, January.
    5. Markus Götz & Olivier Messina & Sergio Espinola & Jean-Bernard Fiche & Marcelo Nollmann, 2022. "Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Dohoon Lee & Jeewon Yang & Sun Kim, 2022. "Learning the histone codes with large genomic windows and three-dimensional chromatin interactions using transformer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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