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Viruses in the faecal microbiota of monozygotic twins and their mothers

Author

Listed:
  • Alejandro Reyes

    (Center for Genome Sciences and Systems Biology, Washington University School of Medicine)

  • Matthew Haynes

    (San Diego State University)

  • Nicole Hanson

    (San Diego State University)

  • Florent E. Angly

    (San Diego State University
    Advanced Water Management Centre, The University of Queensland)

  • Andrew C. Heath

    (Washington University School of Medicine)

  • Forest Rohwer

    (San Diego State University)

  • Jeffrey I. Gordon

    (Center for Genome Sciences and Systems Biology, Washington University School of Medicine)

Abstract

Viral diversity and life cycles are poorly understood in the human gut and other body habitats. Phages and their encoded functions may provide informative signatures of a human microbiota and of microbial community responses to various disturbances, and may indicate whether community health or dysfunction is manifest after apparent recovery from a disease or therapeutic intervention. Here we report sequencing of the viromes (metagenomes) of virus-like particles isolated from faecal samples collected from healthy adult female monozygotic twins and their mothers at three time points over a one-year period. We compared these data sets with data sets of sequenced bacterial 16S ribosomal RNA genes and total-faecal-community DNA. Co-twins and their mothers share a significantly greater degree of similarity in their faecal bacterial communities than do unrelated individuals. In contrast, viromes are unique to individuals regardless of their degree of genetic relatedness. Despite remarkable interpersonal variations in viromes and their encoded functions, intrapersonal diversity is very low, with >95% of virotypes retained over the period surveyed, and with viromes dominated by a few temperate phages that exhibit remarkable genetic stability. These results indicate that a predatory viral–microbial dynamic, manifest in a number of other characterized environmental ecosystems, is notably absent in the very distal intestine.

Suggested Citation

  • Alejandro Reyes & Matthew Haynes & Nicole Hanson & Florent E. Angly & Andrew C. Heath & Forest Rohwer & Jeffrey I. Gordon, 2010. "Viruses in the faecal microbiota of monozygotic twins and their mothers," Nature, Nature, vol. 466(7304), pages 334-338, July.
  • Handle: RePEc:nat:nature:v:466:y:2010:i:7304:d:10.1038_nature09199
    DOI: 10.1038/nature09199
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    Cited by:

    1. Marwan E. Majzoub & Sudarshan Paramsothy & Craig Haifer & Rohit Parthasarathy & Thomas J. Borody & Rupert W. Leong & Michael A. Kamm & Nadeem O. Kaakoush, 2024. "The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Shao-Ming Gao & Han-Lan Fei & Qi Li & Li-Ying Lan & Li-Nan Huang & Peng-Fei Fan, 2024. "Eco-evolutionary dynamics of gut phageome in wild gibbons (Hoolock tianxing) with seasonal diet variations," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Suguru Nishijima & Naoyoshi Nagata & Yuya Kiguchi & Yasushi Kojima & Tohru Miyoshi-Akiyama & Moto Kimura & Mitsuru Ohsugi & Kohjiro Ueki & Shinichi Oka & Masashi Mizokami & Takao Itoi & Takashi Kawai , 2022. "Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Diana P. Baquero & Sofia Medvedeva & Camille Martin-Gallausiaux & Nika Pende & Anna Sartori-Rupp & Stéphane Tachon & Thierry Pedron & Laurent Debarbieux & Guillaume Borrel & Simonetta Gribaldo & Mart , 2024. "Stable coexistence between an archaeal virus and the dominant methanogen of the human gut," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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