IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v465y2010i7300d10.1038_nature09119.html
   My bibliography  Save this article

Developmental sensory experience balances cortical excitation and inhibition

Author

Listed:
  • Anja L. Dorrn

    (Max-Delbrück Center for Molecular Medicine, and NeuroCure Neuroscience Research Center (NWFZ)
    Coleman Memorial Laboratory and W.M. Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA)

  • Kexin Yuan

    (Coleman Memorial Laboratory and W.M. Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA)

  • Alison J. Barker

    (Coleman Memorial Laboratory and W.M. Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA)

  • Christoph E. Schreiner

    (Coleman Memorial Laboratory and W.M. Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA)

  • Robert C. Froemke

    (Coleman Memorial Laboratory and W.M. Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
    Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA)

Abstract

Fine-tuning receptive fields In order to build a proper and stable representation of the auditory world, neonatal rodents exhibit a significant degree of circuit plasticity, allowing for sensitivity to the pattern of sensory inputs. During this time, neurons construct a receptive field, one that relies upon a particular balance of excitatory and inhibitory inputs, yet it is unknown as to how this balance is formed. Two studies published in this issue of Nature reveal contrasting views as to how the mature system develops. Excitation and inhibition were found to be equally strong upon hearing onset in each study. But whereas Dorrn et al. find evidence for an experience-dependent refinement of inhibition as the receptive fields develop, Sun et al. observed a fine adjustment in the excitatory input strength to produce a shifted balance. Nevertheless, taken together, both studies point towards a fine adjustment of synaptic inputs as the force behind the production of mature receptive fields, as opposed to more radical changes such as input pruning.

Suggested Citation

  • Anja L. Dorrn & Kexin Yuan & Alison J. Barker & Christoph E. Schreiner & Robert C. Froemke, 2010. "Developmental sensory experience balances cortical excitation and inhibition," Nature, Nature, vol. 465(7300), pages 932-936, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7300:d:10.1038_nature09119
    DOI: 10.1038/nature09119
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09119
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09119?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li, Xuening & Xie, Ying & Ye, Zhiqiu & Huang, Weifang & Yang, Lijian & Zhan, Xuan & Jia, Ya, 2024. "Chimera-like state in the bistable excitatory-inhibitory cortical neuronal network," Chaos, Solitons & Fractals, Elsevier, vol. 180(C).
    2. Irina Pochinok & Tristan M. Stöber & Jochen Triesch & Mattia Chini & Ileana L. Hanganu-Opatz, 2024. "A developmental increase of inhibition promotes the emergence of hippocampal ripples," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. James M McFarland & Yuwei Cui & Daniel A Butts, 2013. "Inferring Nonlinear Neuronal Computation Based on Physiologically Plausible Inputs," PLOS Computational Biology, Public Library of Science, vol. 9(7), pages 1-18, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:465:y:2010:i:7300:d:10.1038_nature09119. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.