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Nuclear reprogramming to a pluripotent state by three approaches

Author

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  • Shinya Yamanaka

    (Center for iPS Cell Research and Application, Kyoto University
    Gladstone Institute of Cardiovascular Disease)

  • Helen M. Blau

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University)

Abstract

The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three distinct experimental approaches to nuclear reprogramming: nuclear transfer, cell fusion and transcription-factor transduction. Using these approaches, nuclei from 'terminally differentiated' somatic cells can be induced to express genes that are typical of embryonic stem cells, which can differentiate to form all of the cell types in the body. This remarkable discovery of cellular plasticity has important medical applications.

Suggested Citation

  • Shinya Yamanaka & Helen M. Blau, 2010. "Nuclear reprogramming to a pluripotent state by three approaches," Nature, Nature, vol. 465(7299), pages 704-712, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09229
    DOI: 10.1038/nature09229
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    Cited by:

    1. Wei Li & Qi Long & Hao Wu & Yanshuang Zhou & Lifan Duan & Hao Yuan & Yingzhe Ding & Yile Huang & Yi Wu & Jinyu Huang & Delong Liu & Baodan Chen & Jian Zhang & Juntao Qi & Shiwei Du & Linpeng Li & Yang, 2022. "Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ruimin Xu & Qianshu Zhu & Yuyan Zhao & Mo Chen & Lingyue Yang & Shijun Shen & Guang Yang & Zhifei Shi & Xiaolei Zhang & Qi Shi & Xiaochen Kou & Yanhong Zhao & Hong Wang & Cizhong Jiang & Chong Li & Sh, 2023. "Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Chunhe Li & Jin Wang, 2013. "Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths," PLOS Computational Biology, Public Library of Science, vol. 9(8), pages 1-14, August.
    4. Gleb Zyuz’kov, 2019. "The Foresight for Practical Realization of Research in Regenerative Medicine and Cell Technologies," Science Governance and Scientometrics Journal, Russian Research Institute of Economics, Politics and Law in Science and Technology (RIEPL), vol. 14(1), pages 42-69, March.

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