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Progesterone induces adult mammary stem cell expansion

Author

Listed:
  • Purna A. Joshi

    (Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada)

  • Hartland W. Jackson

    (Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada)

  • Alexander G. Beristain

    (Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada)

  • Marco A. Di Grappa

    (Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada)

  • Patricia A. Mote

    (Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia)

  • Christine L. Clarke

    (Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia)

  • John Stingl

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre)

  • Paul D. Waterhouse

    (Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada)

  • Rama Khokha

    (Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada)

Abstract

Mammary stem cell control The ovarian hormones oestrogen and progesterone are involved in a complicated series of interactions in the mammary glands from the beginning of puberty to the menopause. Many of these changes are associated with cell proliferation, and breast cancer can result when errors occur. Two studies in this issue examine the effects of oestrogen and progesterone on mouse mammary stem cell (MaSC) function. They find that MaSC numbers decrease in virgin mice in the absence of both hormones due to ovariectomy or drug blockade, but increase with oestrogen and progesterone treatment. In addition, both groups implicate RANKL, a progesterone target known to be involved in bone remodelling and mammary gland formation, as an intermediary in the MaSC response to progesterone.

Suggested Citation

  • Purna A. Joshi & Hartland W. Jackson & Alexander G. Beristain & Marco A. Di Grappa & Patricia A. Mote & Christine L. Clarke & John Stingl & Paul D. Waterhouse & Rama Khokha, 2010. "Progesterone induces adult mammary stem cell expansion," Nature, Nature, vol. 465(7299), pages 803-807, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09091
    DOI: 10.1038/nature09091
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    Cited by:

    1. Ana Sofia Rocha & Alejandro Collado-Solé & Osvaldo Graña-Castro & Jaime Redondo-Pedraza & Gonzalo Soria-Alcaide & Alex Cordero & Patricia G. Santamaría & Eva González-Suárez, 2023. "Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Maryam Ghaderi Najafabadi & G. Kenneth Gray & Li Ren Kong & Komal Gupta & David Perera & Huw Naylor & Joan S. Brugge & Ashok R. Venkitaraman & Mona Shehata, 2023. "A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Tom W. Andrew & Lauren S. Koepke & Yuting Wang & Michael Lopez & Holly Steininger & Danielle Struck & Tatiana Boyko & Thomas H. Ambrosi & Xinming Tong & Yuxi Sun & Gunsagar S. Gulati & Matthew P. Murp, 2022. "Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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