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The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

Author

Listed:
  • Junko Sasaki

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Satoshi Kofuji

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Reietsu Itoh

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Toshihiko Momiyama

    (Jikei University School of Medicine)

  • Kiyohiko Takayama

    (Global COE Program, Gunma University and Akita University
    Gunma University Graduate School of Medicine)

  • Haruka Murakami

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Shinsuke Chida

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Yuko Tsuya

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Shunsuke Takasuga

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Satoshi Eguchi

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Ken Asanuma

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

  • Yasuo Horie

    (Akita University Graduate School of Medicine)

  • Kouichi Miura

    (Akita University Graduate School of Medicine)

  • Elizabeth Michele Davies

    (Monash University, Clayton, Victoria 3800, Australia)

  • Christina Mitchell

    (Monash University, Clayton, Victoria 3800, Australia)

  • Masakazu Yamazaki

    (Global COE Program, Gunma University and Akita University)

  • Hirokazu Hirai

    (Global COE Program, Gunma University and Akita University
    Gunma University Graduate School of Medicine)

  • Tadaomi Takenawa

    (Kobe University Graduate School of Medicine
    Global COE Program, Kobe University Graduate School of Medicine)

  • Akira Suzuki

    (Global COE Program, Gunma University and Akita University
    Medical Institute of Bioregulation, Kyushu University)

  • Takehiko Sasaki

    (Akita University Graduate School of Medicine
    Global COE Program, Gunma University and Akita University)

Abstract

INPP4A suppression of excitotoxic neuronal death Junko Sasaki and colleagues demonstrate a critical role for inositol polyphosphate phosphatase 4A (INPP4A), a PtdIns(3,4)P2 phosphatase, in maintaining the integrity of the brain. Mice that lack INPP4A have neurodegeneration in the striatum and suffer from severe involuntary movements. They further show that INPP4A, when present, protects neurons from NMDA type glutamate receptor-mediated excitotoxic cell death. The authors present evidence to suggest that INPP4A can keep neurons alive by downregulating NMDARs and thus decreasing cellular sensitivity to glutamate stimulation.

Suggested Citation

  • Junko Sasaki & Satoshi Kofuji & Reietsu Itoh & Toshihiko Momiyama & Kiyohiko Takayama & Haruka Murakami & Shinsuke Chida & Yuko Tsuya & Shunsuke Takasuga & Satoshi Eguchi & Ken Asanuma & Yasuo Horie &, 2010. "The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death," Nature, Nature, vol. 465(7297), pages 497-501, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7297:d:10.1038_nature09023
    DOI: 10.1038/nature09023
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    Cited by:

    1. Kaori Kanemaru & Makoto Shimozawa & Manabu Kitamata & Rikuto Furuishi & Hinako Kayano & Yui Sukawa & Yuuki Chiba & Takatsugu Fukuyama & Junya Hasegawa & Hiroki Nakanishi & Takuma Kishimoto & Kazuya Ts, 2022. "Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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