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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

Author

Listed:
  • Yingdi Wang

    (Vascular Development Laboratory, Cancer Research UK London Research Institute)

  • Masanori Nakayama

    (Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster)

  • Mara E. Pitulescu

    (Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster)

  • Tim S. Schmidt

    (Vascular Development Laboratory, Cancer Research UK London Research Institute)

  • Magdalena L. Bochenek

    (Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster
    School of Medical Sciences, University of Bristol)

  • Akira Sakakibara

    (Vascular Development Laboratory, Cancer Research UK London Research Institute)

  • Susanne Adams

    (Vascular Development Laboratory, Cancer Research UK London Research Institute
    Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster)

  • Alice Davy

    (Centre de Biologie du Développement, Université de Toulouse, CNRS, CBD UMR 5547, F-31062 Toulouse cedex 9, France)

  • Urban Deutsch

    (Theodor Kocher Institute, University of Berne)

  • Urs Lüthi

    (Oncalis AG)

  • Alcide Barberis

    (Oncalis AG)

  • Laura E. Benjamin

    (Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215-5501, USA)

  • Taija Mäkinen

    (Cancer Research UK London Research Institute, Lymphatic Development Laboratory)

  • Catherine D. Nobes

    (School of Medical Sciences, University of Bristol)

  • Ralf H. Adams

    (Vascular Development Laboratory, Cancer Research UK London Research Institute
    Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster)

Abstract

Ephrin-B2/VEGF in angiogenesis control Ephrin-B ligands are well known as axon guidance molecules. Ephrin-B2 is also known to play a role in angiogenic remodelling. Two studies now show that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating VEGFR internalization and signalling. The finding suggests that blocking ephrin-B2 signalling may be an alternative approach to blocking VEGFR function in angiogenesis.

Suggested Citation

  • Yingdi Wang & Masanori Nakayama & Mara E. Pitulescu & Tim S. Schmidt & Magdalena L. Bochenek & Akira Sakakibara & Susanne Adams & Alice Davy & Urban Deutsch & Urs Lüthi & Alcide Barberis & Laura E. Be, 2010. "Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis," Nature, Nature, vol. 465(7297), pages 483-486, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7297:d:10.1038_nature09002
    DOI: 10.1038/nature09002
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